Custom Peptides
Cayman Chemical Naloxon benzoylhydrazon 10mg
A μ-, κ1-, and δ-opioid receptor antagonist (pA2s = 8.82, 7.45, and 7.76, respectively, for the mouse receptors); a κ3-opioid receptor agonist (IC50 = 0.7 nM for the guinea pig receptor); inhibits increases in the latency to tail withdraw induced by DAMGO in a hotplate assay in mice at 1 UG/animal, i.c.v.; increases food intake in rats at 0.1, 1, and 20 UG/animal, i.c.v.
Cayman Chemical FerroptosIs Inducer 24 10mg
An inducer of ferroptosis; inhibits GPX4 by 30-35% at 50 µM; increases the levels of HO-1 in MDA-MB-231 cancer cells, as well as increases HO-1 bilirubin formation activity in MDA-MB-231 cell lysates at 10 µM; reduces the viability of, as well as increases the levels of oxidized lipids, decreases the levels of IL-6 and GST, and disrupts the mitochondrial membrane potential in, MDA-MB-231 cells at 50 µM; increases the levels of ROS in a time-dependent manner
Cayman Chemical JNJ47117096trIfluoroACTAt 10mg
A MELK inhibitor (IC50 = 37 nM); selective for MELK over CAMKIIδ, MNK2, CAMKIIγ, and MLCK (IC50s = 810, 760, 1,000, and 1,000 nM, respectively) but does inhibit FLT3 (IC50 = 18 nM); inhibits MELK autophosphorylation (IC50 = 0.52 µM) and MELK proteasome-dependent degradation in MCF-7 cells; induces cellular senescence and the ATM-mediated DNA damage response in MCF-7 cells
Cayman Chemical Q1-SM-102IodIde 10mg
A cationic quaternary ammonium lipid derivative of SM-102; LNPs containing Q1-SM-102 and SM-102 as a CLP and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice
Cayman Chemical 2-OxoadIpIc AcId 10mg
An intermediate in the catabolism of L-tryptophan, L-lysine, and hydroxylysine; urinary excretion is increased in patients with α-ketoadipic aciduria
Cayman Chemical DIhydrofolIc AcId 10mg
An active metabolite of folic acid; formed via the NADH-dependent reduction of folic acid by DHFR; reduces IGF-1R promoter activity in a cell-based reporter assay at 10, 50, and 100 UG/ml
Cayman Chemical IsoscopoletIn 10mg
A coumarin with diverse biological activities and an active metabolite of scoparone; cytotoxic to A549, MCF-7, and HepG2 cells (IC50s = 5.25, 8.58, and 4.76 µM, respectively); active against S. aureus and E. coli in agar diffusion assays; inhibits 15-LO (IC50 = 15.1 µM); reduces paw thickness in a rat model of carrageenan-induced paw edema at 0.1 mg/kg
Cayman Chemical SalmeterolxInafoate 10mg
A long-acting β2-AR agonist (EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively); inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM); inhibits histamine-induced bronchoconstriction in guinea pigs via aerosol administration at 0.12-12 mM
Cayman Chemical Hexnoyl GlycIn 10mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation
Cayman Chemical 3 4MethylendIoxyaPyrrolId 10mg
An analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain; intended for forensic and research applications
Cayman Chemical ABCHMINACA metabolIte M1A 10mg
A monohydroxylated metabolite of AB-CHMINACA; intended for forensic and research applications
Cayman Chemical IsorhamntIn 10mg
A natural flavonol aglycone that has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM); competitively inhibits MATE1, Ki = 0.32 µM); potentiates the neurological actions of nerve growth factor, diminishes the cardiotoxic impact of doxorubicin, and can have beneficial anti-cancer effects
Cayman Chemical 4fluoroaPyrroldInopentIop 10mg
An isomer of α-PVP characterized by the addition of a fluorine group at the 4 position of the phenyl ring; intended for forensic and research applications
Cayman Chemical JWH 018 NpropNIc ACD meta 10mg
A major metabolite of JWH 018 that is detectable in urine; this analytical reference standard is intended for forensic and research applications only
Cayman Chemical 1Naphthoyl2methylIndole 10mg
An analytical reference standard categorized as a precursor in the synthesis of synthetic cannabinoids; intended for research and forensic applications