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Albumin is the most abundant plasma protein in humans. It accounts for ~60% of the total serum protein. Albumin plays important physiological roles including maintenance of colloid osmotic pressure and binding of key substances such as long-chain fatty acids bile acids bilirubin hematin calcium and magnesium. It has antioxidant and anticoagulant effects acts as a carrier for nutritional factors and drugs and is an effective plasma pH buffer. Serum albumin is a reliable prognostic indicator for morbidity and mortality liver disease nephritic syndrome malnutrition and protein-losing enteropathies. High levels are associated with dehydration.
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