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p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells mediating tumor enrichment of radioactive probes p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR such as prostate cancer and colorectal cancer[1][2]
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4-Thio-UTP is a nucleotide triphosphate analog in which the oxygen atom at the 4-position of uracil is substituted by a sulfur atom It can be incorporated into RNA molecules during in vitro transcription reactions producing RNAs containing 4-thiouridine modifications This modification provides unique advantages in studying protein interactions RNA modifications and RNA labeling Due to the presence of the sulfur atom RNA modified with 4-Thio-UTP can form cross-links with proteins upon ultraviolet (UV) irradiation facilitating the study of RNA-protein interactions Additionally 4-Thio-UTP can be employed in research on RNA folding and function as well as in studying the cellular localization and roles of RNA
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This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1.
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