Nucleic Acid Synthesis
Medchemexpress LLC Trifluridine/tipiracil hydrochloride mixture | 733030-01-8 | 99.98% | 435.76 | 1ML
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. It is a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 exerts its antitumor activity primarily by inhibiting thymidylate synthase (TS) and incorporating into DNA. In vivo, it has been shown to prevent body weight loss and reduce relative tumor volume in colorectal and gastric cancer mouse models. Several clinical trials are associated with TAS-102 for various conditions like Colorectal Cancer and Gastric Adenocarcinoma.
- Potent and orally active nucleoside antitumor agent
- Mixture of tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI)
- Inhibits thymidylate synthase (TS)
- Incorporates into DNA for antitumor activity
- Reduces tumor volume in mouse models
Cayman Chemical 4-deoxy PyrIdoxInhydrochlo 1g
A vitamin B6 antimetabolite; inhibits transport of pyridoxine, pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells; inhibits S1P lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells; decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy; reduces TNF-α and IL-6 production in mice infected with T. spiralis
BLD PHARMATECH CO LIMITED ((2R,3R,4R,5R)-3-Acetoxy-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methyl acetate,1188522-91-9
((2R,3R,4R,5R)-3-Acetoxy-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methyl acetate,1188522-91-9
Sigma Aldrich Fine Chemicals Biosciences DMT-dG(dmf) Phosphoramidite configured for MerMade | 330628-04-1 | MFCD00797420 | 6X5G
DMT-dG(dmf) Phosphoramidite configured for MerMade | Purity: >=99 (31P-NMR); >=99.0% (reversed phase HPLC) | Mol Wt: 824.9 | 330628-04-1 | MFCD00797420 | 6X5G
Sigma Aldrich Fine Chemicals Biosciences DMT-dG(dmf) Phosphoramidite configured for ABI | 330628-04-1 | MFCD00797420 | 12X2G
DMT-dG(dmf) Phosphoramidite configured for ABI | Purity: >=99 (31P-NMR); >=99.0% (reversed phase HPLC) | Mol Wt: 824.9 | 330628-04-1 | MFCD00797420 | 12X2G
Sigma Aldrich Fine Chemicals Biosciences DMT-dG(dmf) Phosphoramidite configured for PerkinElmer, configured for Polygen | 330628-04-1 | MFCD00797420 | 12X2G
DMT-dG(dmf) Phosphoramidite configured for PerkinElmer, configured for Polygen | Purity: >=99 (31P-NMR); >=99.0% (reversed phase HPLC) | Mol Wt: 824.9 | 330628-04-1 | MFCD00797420 | 12X2G
Medchemexpress LLC P62-mediated mitopha 25mg | 1809031-84-2 | 392.15 g/mol | C14H9IN4O2 | 25 MG
P62-mediated mitophagy inducer is a small-molecule research compound that selectively activates p62-dependent mitophagy without recruiting Parkin or collapsing mitochondrial membrane potential. It is intended for in vitro and cellular research applications and is not for human or clinical use.
- Activates p62-dependent mitophagy in cellular models.
- Does not recruit Parkin or disrupt mitochondrial membrane potential.
- Solid powder, light yellow to yellow, suitable for laboratory handling.
- High purity (99.54%) for biochemical and cellular assays.
- Stable when stored under recommended conditions (powder: -20°C).
Sigma Aldrich Fine Chemicals Biosciences DMT-2'O-TC-rU Phosphoramidite configured for ABI | 1219089-92-5 | MFCD19105660 | 1G
DMT-2'O-TC-rU Phosphoramidite configured for ABI | Purity: >=98% (31P-NMR); >=98.0% (reversed phase HPLC) | Mol Wt: 924.03 | 1219089-92-5 | MFCD19105660 | 1G