Nucleotides
Sigma Aldrich Fine Chemicals Biosciences Digoxigenin 11 UTP
Digoxigenin (DIG) -11-uridine triphosphate (UTP) is provided as a SOLUTIONon of the tetralithium salt in 3.5mM (200nmol) or 10mM (250nmol) concentration. It is used as a substrate for SP6 T3 and T7 RNA polymerases. It can replace UTP in the in vitro transcription reaction for DIG labeling of RNA in a ratio of 3565%.
Sigma Aldrich Fine Chemicals Biosciences Deoxynucleotide Mix 10 mM
Nucleotides are organic molecules that serve as the monomers or subunits of nucleic acids (like DNA and RNA). The building blocks of nucleic acids nucleotides consist of a nitrogenous base (purine or pyrimidine) a five-carbon sugar (ribose or deoxyribose) and at least one phosphate group. A nucleoside along with a phosphate group yields a nucleotide.
Cayman Chemical Grnzyme B MoncLNal ntIbod 50uL
An a-glucosidase inhibitor (IC50 0.7 Ug/ml) and a prodrug form of castanospermine reduces BVDV levels in a plaque formation assay (IC50 16 mM) and increases survival of MDBK infected with BVDV (IC50 47 UM) reduces viremia and increases survival of mice infected with a lethal dose of dengue virus at 50 mg/kg twice daily i.p.
Cayman Chemical FluoresceIn-12-dCTP 25nmol
A fluorescent membrane potential indicator displays excitation/emission maxima of 490/516 nm respectively has been used to measure the membrane potential of live or fixed mammalian and bacterial cells by flow cytometry or fluorescence microscopy
Cayman Chemical FluoresceIn-12-dATP 25nmol
A Y-glutamyl dipeptide a kokumi compound has been found in several ripened cheeses as well as sourdough bread fermented with L reuteri
Cayman Chemical SynthetIc TubercIdIn 25mg
A sesquiterpene lactone with diverse biological activities inhibits proliferation of PANC-1 BxPC-3 and HPAC pancreatic cancer cells (IC50s 40 43 and 48 UM respectively) induces apoptosis cell cycle arrest at the S phase and the production of ROS in PANC-1 cells decreases LPS-induced production of NO PGE2 IL-6 and TNF-a in RAW 264 7 macrophages at 4 and 8 UM reduces production of S aureus a-toxin in a concentration-dependent manner and increases survival in a mouse model of S aureus-induced pneumonia at 50 mg/kg
Cayman Chemical N6 N6-DImethyladenosIn 500mg
A positive allosteric modulator of mGluR5 potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s 10 and 20 nM for the human and rat receptor respectively) inhibits amphetamine-induced PPI disruptions in rats at 30 mg/kg s c
Cayman Chemical BODIPY 508CholSTRyl Ol
A cell-permeable stearated peptide decreases PKA membrane anchoring but not activity in a reporter assay using BHK-21 fibroblasts at 50 UM reduces capacitance hyperactivation as well as prevents in vitro fertilization in mouse sperm at 1 and 3 UM increases cholesterol export from ABCA1-expressing BHK-21 cells and RAW 264.7 macrophages at 50 UM
Cayman Chemical InfluenzaA Nucleprot Mono 50uL
An inhibitor of ALK5 (IC50 2.5 nM) selective for ALK5 over p38 MAPK (IC50 12 UM) reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats at 1 3 and 10 mg/kg reduces proteinuria and glomerulosclerosis and improves renal function in heminephrectomized rats in a model of anti-Thy-1 glomerulonephritis at 0.3 and 1 mg/kg
Cayman Chemical 8-BromogunosIn-5-O-trIphos 3mg
A dicarboxylic acid and a derivative of 3-methylglutaric acid is decreased by 5-aza-2-deoxycytidine in several bladder cancer cell lines
Cayman Chemical 3-Deaza-2-deoxyadenosIn 1mg
A SERD selectively induces degradation of ERa in MCF-7 cancer cells (EC50 0.2 nM) over ERB glucocorticoid androgen progesterone and mineralocorticoid receptors at 5 UM but does activate ERB signaling in reporter cells decreases 17B-estradiol-induced proliferation of MCF-7 cells expressing wild-type ERa MCF-7 cells expressing ERaY537S and MCF-7 cells expressing ERaD538G (EC50s 20 331 and 595 nM respectively) reduces tumor volume in a PDX mouse model of tamoxifen-resistant breast cancer
Cayman Chemical 3-Deaza-2-deoxyadenosIn 5mg
A SERD selectively induces degradation of ERa in MCF-7 cancer cells (EC50 0.2 nM) over ERB glucocorticoid androgen progesterone and mineralocorticoid receptors at 5 UM but does activate ERB signaling in reporter cells decreases 17B-estradiol-induced proliferation of MCF-7 cells expressing wild-type ERa MCF-7 cells expressing ERaY537S and MCF-7 cells expressing ERaD538G (EC50s 20 331 and 595 nM respectively) reduces tumor volume in a PDX mouse model of tamoxifen-resistant breast cancer
Cayman Chemical Caspase4 InhIbItrAcLEVD 25uL
A GCGR antagonist reduces glucagon-induced hyperglycemia in wild-type mice reduces blood glucose levels in mouse models of diabetes