RNAi Controls
Genscript Corporation CD52 hFc Chimera Mouse
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation CD164 hFc Chimera Mouse
CD164 was found to play a role in many malignant diseases CD164 was associated with clinical and pathological features of patients High level of CD164 was related to the distant metastasis and vascular invasion of bladder cancer patients CD164 was associated with the poor clinical outcomes of BC patients Silencing of CD164 could inhibit the progression of tumors in vivo and in vitro which may become an effective target in the treatment of bladder cancer
Genscript Corporation TROP-2/TACSTD2 hFc Chimera Hu
Trop-2 also known as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene Mutations of this gene result in gelatinous drop-like corneal dystrophy an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness
Genscript Corporation CD47 hFc Chimera Mouse
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Genscript Corporation Her3/ErbB3 hFc Chimera Human
Her3 also called ErbB3 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors Her3 is expressed in keratinocytes melanocytes skeletal muscle cells embryonic myoblasts and Schwann cells Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG)
Genscript Corporation TROP-2/TACSTD2 hFc Chimera Hu
Trop-2 also known as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene Mutations of this gene result in gelatinous drop-like corneal dystrophy an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness
Genscript Corporation Siglec-15/CD33L3 hFc Chimera
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains a 21 aa transmembrane segment and a 44 aa cytoplasmic domain Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates
Genscript Corporation FGFR2 beta IIIb hFc Chimera
Four distinct genes encoding closely related FGF receptors FGFR1-4 are known All four genes for FGFRs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid-box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain Multiple forms of FGFR1-3 are generated by alternative splicing of the mRNAs A frequent splicing event involving FGFR1 and 2 results in receptors containing all three Ig domains referred to as the alpha isoform or only IgII and IgIII referred to as the beta isoform
Genscript Corporation CD47 hFc Chimera Mouse
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Genscript Corporation CD30/TNFRSF8 hFc Chimera Huma
The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153 TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions CD30 expression is upregulated in various hematological malignancies including Reed-Sternberg cells in Hodgkin s disease (HD) anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin s lymphomas (NHLs)
Genscript Corporation CD27/TNFRSF7 mFc Chimera Mous
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD200 R1/CRTR2 hFc Chimera Hu
CD200Fc a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region regulates immune responses following engagement of a cell surface receptor CD200R expressed on cells of the myeloid and T cell lineage A recent report focused attention on a family of CD200Rs but concluded that only one member used CD200 as its ligand
Genscript Corporation VEGF R3/FLT4 hFc Chimera Huma
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1 -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors VEGF-R1 -R2 and -R3 were highly expressed in CRC cells and stromal vessels VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery
Genscript Corporation CD160 Fc Chimera Human
CD160 is a glycosylphosphatidylinositol-anchored Ig domain protein that is expressed on almost all intestinal intraepithelial lymphocytes (IELs) T (gamma delta T) cells NK (natural killer) cells and a minor subset of CD4 and CD8 T cells In terms of function work has centered on the role of CD160 in enhancing NK or CD8 T cell activation Such effects have been attributed to the ability of CD160 to bind classical and nonclassical MHC class I molecules although with apparent low affinity requiring clustering of MHC class I molecules or overexpression of CD160 or MHC class I for detection of the interaction
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain