RNAi Controls
Genscript Corporation CD47 hFc Chimera Human
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Genscript Corporation CD98 hFc Chimera Human
The type II transmembrane protein CD98 best known as the heavy chain of the heterodimeric amino acid transporters (HAT) is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells
Genscript Corporation EGFR/HER1 hFc Chimera Human
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands The epidermal growth factor receptor is a member of the ErbB family of receptors a subfamily of four closely related receptor tyrosine kinases EGFR HER2/neu Her 3 and Her 4 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Genscript Corporation CD160 hFc Chimera Human
CD160 (also Natural killer cell receptor BY55) is a 27 30 kDa member of the Ig superfamily In human it is expressed principally on nonmyeloid hematopoietic cells CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation Exists as a GPI-anchored and as a transmembrane form each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
Genscript Corporation CD27/TNFRSF7 hFc Chimera Cyno
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD37 hFc Chimera Human
CD37 is a tetraspanin expressed prominently on the surface of B cells It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia Currently several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials Given the unique role of CD37 in the biology of B cells it seems that CD37 constitutes more than a docking point for monoclonal antibodies and targeting this molecule may provide additional benefit to relapsed or refractory patients
Genscript Corporation CD28H/IGPR-1 hFc Chimera Huma
CD28H is constitutively expressed on all naive T cells Repetitive antigenic exposure however induces a complete loss of CD28H on many T cells and CD28H negative T cells have a phenotype of terminal differentiation and senescence After extensive screening in a receptor array a B7-like molecule B7 homologue 5 (B7-H5) was identified as a specific ligand for CD28H
Genscript Corporation EGFR/HER1 hFc Chimera Human
The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands The epidermal growth factor receptor is a member of the ErbB family of receptors a subfamily of four closely related receptor tyrosine kinases EGFR HER2/neu Her 3 and Her 4 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses
Genscript Corporation CD160 Fc Chimera Human
CD160 is a glycosylphosphatidylinositol-anchored Ig domain protein that is expressed on almost all intestinal intraepithelial lymphocytes (IELs) T (gamma delta T) cells NK (natural killer) cells and a minor subset of CD4 and CD8 T cells In terms of function work has centered on the role of CD160 in enhancing NK or CD8 T cell activation Such effects have been attributed to the ability of CD160 to bind classical and nonclassical MHC class I molecules although with apparent low affinity requiring clustering of MHC class I molecules or overexpression of CD160 or MHC class I for detection of the interaction
Genscript Corporation TNFRSF12A/TWEAKR hFc Chimera
Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer in addition PPAR signaling pathway insulin signaling pathway mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A
Genscript Corporation CD161 hFc Chimera Human
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD3ECD3D hFc Chimera Mouse
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD27/TNFRSF7 hFc Chimera Huma
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis