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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
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The R-Plex Human LRRK2 pS935 Assay Kit from Meso Scale Diagnostics measures LRRK2 phosphorylated at serine 935 in human samples using electrochemiluminescence The assay uses a plate pre-coated with a capture antibody for total LRRK2 Samples bind to this antibody and a detection antibody for phospho-LRRK2 is added forming a sandwich complex A read buffer generates a signal proportional to phospho-LRRK2 levels The kit includes a plate detection antibody read buffer sample diluent and lyophilized calibrator
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Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85 55 or 50 kD This gene encodes the 85 kD regulatory subunit Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin and a mutation in this gene has been associated with insulin resistance Alternative splicing of this gene results in four transcript variants encoding different isoforms [provided by RefSeq Jun 2011]
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Immunogen: Full-length human recombinant ATG5 protein • Host: Mouse • Species Reactivity: (+) Human; other species not tested • Cross Reactivity: (-) ATG8 • Applications: ELISA, IHC, and WB • MW: ~56 kDa for the ATG5-ATG12 complex
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The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis This protein functions as a cellular oxygen sensor and under normal oxygen concentration modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3)
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