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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
The R-Plex Human p38 [pT180/pY182] Assay Kit from Meso Scale Discovery is used to quantitatively measure the levels of phosphorylated p38 MAPK at threonine 180 and tyrosine 182 in cell lysates This electrochemiluminescent assay utilizes MSD s patented SULFO-TAG labels and multi-array plate technology to provide high sensitivity low background and a wide dynamic range The kit includes a 96-well plate pre-coated with capture antibody detection antibody conjugated to ruthenium read buffer wash buffer blocker solutions calibrator and positive control lysate This assay allows for the rapid reproducible quantification of phospho-p38 levels for studying cellular signaling pathways
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Rab12 a member of the RAS oncogene family is crucial for intracellular membrane trafficking This small GTPase protein mediates vesicle transport particularly from recycling endosomes to lysosomes playing a key role in autophagy and transferrin receptor degradation Rab12 cycles between inactive GDP-bound and active GTP-bound forms recruiting effectors for vesicle formation movement and fusion It is phosphorylated by LRRK2 which it also regulates Rab12 activates LRRK2 leading to increased phosphorylation of Rab10 aiding in lysosomal function Dysregulation of this pathway especially due to pathogenic LRRK2 mutations may contribute to neurodegenerative processes in Parkinson s disease
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More