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The TLR4 agonist, MPLA (monophosphoryl lipid A) is a derivative of lipid A from Salmonella minnesota R595 lipopolysaccharide (LPS or endotoxin). MPLA is considerably less toxic than LPS whilst maintaining immunostimulatory activity.
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Alhydrogel adjuvant 2% is an aluminium hydroxide (referred to as alum) wet gel suspension. Alum acts primarily through the formation of a depot at the injection site, enabling enhanced antigen availability, activation of antigen presenting cells (APCs) and uptake by immune cells. It can also activate innate immunity pathways triggered by pattern recognition receptors (PRRs). The NLR pathway has been recently described as an important mechanism in alum adjuvancy. Alum has been shown to activate the NLRP3 inflammasome although its role in alum-induced antibody response is controversial. 21645-51-2.
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Squalene is a naturally occurring triterpenoid synthesized from two molecules of farnesyl diphosphate (FPP) by squalene synthase. Echelons squalene has been further purified to remove oxidized byproducts. This item is non returnable
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FA (Incomplete Freunds adjuvant) is one of the most commonly used adjuvants in research. It is prepared from non-metabolizable oils.IFA can be used to produce water-in-oil emulsions of antigens.IFA induces a predominantly Th2-biased response through the formation of a depot at the injection site and the stimulation of antibody producing plasma cells. INVIVOGEN mfg# VAC-IFA-60
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The imidazoquinoline compound Imiquimod is a guanosine derivative and agonist for TLR7. This TLR7 agonist, originally developed as type I IFN inducers, is an effective adjuvant by activating dendritic cells (DCs) and B cells to induce cytokines optimal for Th1 cell immunity, and antibody production.
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