Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Tocris Bioscience™ PF 06651600 malonate
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Offers one or more environmental benefits itemized in the U.S. FTC Green Guides.
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Potent and selective JAK3 inhibitor
| CAS | 2140301-97-7 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C15H19N5O.C3H4O4 |
Tocris Bioscience™ EPZ 015666
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Potent and selective PRMT5 inhibitor
| CAS | 1616391-65-1 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H25N5O3 |
| Formula Weight | 383.44 |
Tocris Bioscience™ Suramin hexasodium salt
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Non-selective P2 antagonist
Tocris Bioscience™ JPS036
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Selective HDAC3 Degrader (PROTAC™)
Tocris Bioscience™ GSK 2239633A
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Potent CCR4 antagonist
| CAS | 1240516-71-5 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide |
| Molecular Formula | C24H25ClN4O5S2 |
Tocris Bioscience™ T4
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Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3
| Target | DNA, RNA and Protein Synthesis Compounds |
|---|---|
| CAS | 785708-33-0 |
| Purity | 0.98 |
| Chemical Name or Material | 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C22H23N3O3 |
Tocris Bioscience™ AS 99
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Selective ASH1L histone methyltransferase inhibitor
Tocris Bioscience™ BL660-NO
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Nitric oxide activity-based sensing NIR bioluminescent probe
Tocris Bioscience™ 6 TMR Tre
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Fluorescent trehalose conjugate for imaging bacterial cell envelope
Tocris Bioscience™ GSK 1702934A
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Potent and selective TRPC3/6 activator
| CAS | 924377-85-5 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C22H25N3O2S |
| Formula Weight | 395.52 |
Tocris Bioscience™ GT 949
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Potent and selective positive allosteric modulator of EAAT2
| CAS | 460330-27-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C30H37N7O2 |
Tocris Bioscience™ CPS2
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Potent and selective CDK2 Degrader (PROTAC™)
Tocris Bioscience™ IRAK3 Degrader 23
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IRAK3 PROTAC™ Degrader