Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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661
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661
Tocris Bioscience™ BAY 805
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective inhibitor of USP21; also NF-κB activator
| Target | Deubiquitinating Enzyme Inhibitors |
|---|---|
| CAS | 2925481-88-3 |
| Purity | 0.98 |
| Chemical Name or Material | N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H28F3N5O2S |
662
Tocris Bioscience™ TL 13-12
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective ALK Degrader (PROTAC™)
663
Tocris Bioscience™ O8 OGG1 Inhibitor
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay)
| CAS | 350997-39-6 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C9H6Cl2N2OS |
| Formula Weight | 261.13 |
664
Tocris Bioscience™ ent-LP 99
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Negative Control for LP 99
| CAS | 1808948-28-8 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[(2S,3R)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C26H30ClN3O4S |
| Formula Weight | 516.05 |
665
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Thermo Scientific Chemicals Rofecoxib
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Thermo Scientific Chemicals Rofecoxib
CAS: 162011-90-7 Molecular Formula: C17H14O4S Molecular Weight (g/mol): 314.36 InChI Key: RZJQGNCSTQAWON-UHFFFAOYSA-N IUPAC Name: 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one SMILES: CS(=O)(=O)C1=CC=C(C=C1)C1=C(C(=O)OC1)C1=CC=CC=C1
| CAS | 162011-90-7 |
|---|---|
| Molecular Weight (g/mol) | 314.36 |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C1=C(C(=O)OC1)C1=CC=CC=C1 |
| IUPAC Name | 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one |
| InChI Key | RZJQGNCSTQAWON-UHFFFAOYSA-N |
| Molecular Formula | C17H14O4S |
666
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Thermo Scientific Chemicals Cyclobenzaprine hydrochloride
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Thermo Scientific Chemicals Cyclobenzaprine hydrochloride
CAS: 6202-23-9 Molecular Formula: C20H22ClN
| CAS | 6202-23-9 |
|---|---|
| Molecular Formula | C20H22ClN |
667
Tocris Bioscience™ Risdiplam
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Selective SMN2 gene splicing modifier
| Target | DNA, RNA and Protein Synthesis Compounds |
|---|---|
| CAS | 1825352-65-5 |
| Purity | 0.98 |
| Chemical Name or Material | 7-(4,7-Diazaspiro[2.5 ]oct-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4 H-pyrido[1,2-a]pyrimidin-4-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C22H23N7O |
668
Tocris Bioscience™ CG 428
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent tropomyosin receptor kinase (TRK) degrader
669
Tocris Bioscience™ PEAQX tetrasodium salt
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent and GluN2A-selective NMDA antagonist
670
Tocris Bioscience™ AP 14145 hydrochloride
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Small and Specialty Supplier Partner
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Negative allosteric modulator of KCa2 (SK) channels
671
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Thermo Scientific Chemicals Metamizole sodium monohydrate
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Thermo Scientific Chemicals Metamizole sodium monohydrate
CAS: 5907-38-0 Molecular Formula: C13H18N3NaO5S
| CAS | 5907-38-0 |
|---|---|
| Molecular Formula | C13H18N3NaO5S |
672
Tocris Bioscience™ AKT Inhibitor IV
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
673
Tocris Bioscience™ A 410099.1 amide-PEG3-amine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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IAP ligand with PEG linker and terminal amine for onward chemistry
674
Tocris Bioscience™ VH 032 amide-alkylC7-acid
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Small and Specialty Supplier Partner
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VHL ligand with alkyl linker and terminal acid for onward chemistry
675
Tocris Bioscience™ iP300v
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Small and Specialty Supplier Partner
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Negative control for iP300w (Cat. No. 7270)