Crosslinking, Labeling and Protein Modification
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 5mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Broadpharm Fmoc-N-Amido-PEG8-Acid, 5 g, CAS 756526-02-0, Solid or viscous liquid, 98% purity, Linear, dPEG spacer, 8 PEG units
Fmoc-N-Amido-PEG8-Acid is a versatile heterobifunctional polyethylene glycol (PEG) linker specifically designed for applications in bioconjugation, including peptide synthesis and Antibody-Drug Conjugates (ADCs). This product features a unique Fmoc-protected amine and a terminal carboxylic acid, offering two anchor points for modifications. The hydrophilic PEG8 spacer enhances solubility in aqueous media, improving the pharmacokinetic properties of peptides and extending their circulation times in vivo.
- Designed for versatile modifications with two distinct functional groups.
- Improves water solubility and expands hydrodynamic volume.
- Reduces renal clearance and protects peptides from proteolysis.
- Facilitates stable amide bond formation with primary amines using activators.
- Stable under -20°C storage conditions.
- Shipping is done at ambient temperature.
Mitegen PEG 300, 100%(v/v), 100 ml, CAS# 25322-68-3
Use our stock solutions directly or as a component in solutions you create in your own lab. We prepare our stock solutions using high quality raw materials, ASTM Type 1 water, and sterile packaging. Our stock solutions are intended for Research and Development Use Only.
Cayman Chemical Boc-NH-PEG3-CH2CoH 50mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
Medchemexpress LLC Dibenzocyclooctyne-s-s-peg3-biotin | 1430408-09-5 | MFCD28334542 | 96.9% | C42H56N6O8S3 | 10MG
DBCO-S-S-PEG3-biotin is a cleavable, PEG-based linker bearing a DBCO moiety for strain-promoted alkyne-azide cycloaddition. It enables copper-free click conjugation of biotin to azide-containing biomolecules and functions as a disulfide-cleavable linker for applications such as affinity enrichment and PROTAC synthesis. The material is supplied as a solid and is stored under inert atmosphere for stability.
- Cleavable disulfide linker for controlled release
- Compatible with copper-free click chemistry (SPAAC)
- High purity: 96.9%
- Soluble in DMSO at 100 mg/mL (requires ultrasonic)
- Suitable for bioconjugation, affinity enrichment, and linker synthesis
Broadpharm Tamra-PEG3-azide | 1228100-59-1 | MFCD28334528 | 25 mg
Tamra-PEG3-azide | Mol Wt: 646.741 | 1228100-59-1 | MFCD28334528 | 25 mg
Medchemexpress LLC Cholesterol-PEG-MAL | 95.1% | 2000 (average) | 5 MG
Cholesterol-PEG-MAL (MW 2000) is a PEGylated cholesterol derivative bearing a terminal maleimide group. It self-assembles in aqueous media and is used to form liposomes, micelles, and nanoparticles, and to conjugate thiol-containing molecules via maleimide-thiol chemistry. Intended for research use only.
- Reactive maleimide end group enables stable thiol conjugation.
- Amphiphilic cholesterol-PEG structure promotes self-assembly into liposomes and micelles.
- Average molecular weight ~2000 provides steric stabilization in formulations.
- Available in small research quantities suitable for formulation development.
- Documentation available for quality verification and handling.
![eMolecules N-(Azido-PEG1)-N-bis(PEG3-acid), HCl salt | Broadpharm |538.595 | C22H42N4O11 | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)CCOCCN=[N+]=[N-] | 100mg | 704981177](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502479914.JPG-250.jpg)
eMolecules N-(Azido-PEG1)-N-bis(PEG3-acid), HCl salt | Broadpharm |538.595 | C22H42N4O11 | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)CCOCCN=[N+]=[N-] | 100mg | 704981177
N-(Azido-PEG1)-N-bis(PEG3-acid), HCl salt | Broadpharm |538.595 | C22H42N4O11 | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)CCOCCN=[N+]=[N-] | 100mg | 704981177
eMolecules 2250056-53-0 | Medchem Express | HO-PEG10-CH2COOH | 100mg | 788478193 | HY-133304 | 516.581 | C22H44O13
3,5-Dihydroxyacetophenone | Ambeed | 51863-60-6 | MFCD00002290 | 152.149 | C8H8O3 | 97.000 | CC(=O)c1cc(O)cc(O)c1 | 25g | 552531834
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC (S,R,S)-AHPC-(C3-PEG)2-C6-Cl | 1835705-61-7 | MFCD31560481 | 99.9% | 749.44 g/mol | C39H61ClN4O6S | 1 G
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a HaloPROTAC that couples the (S,R,S)-AHPC VHL ligand to a two-unit PEG linker and a C6-chloroalkyl HaloTag reactive group. It is used in cell-based assays to recruit the von Hippel-Lindau (VHL) E3 ligase and promote degradation of HaloTag fusion proteins.
- VHL ligand with PEG linker for E3 ligase recruitment.
- Induces degradation of HaloTag fusion proteins in cell assays.
- High purity for research applications (99.9%).
- Solid form, supplied as a 1 g laboratory package.
- Store at -80°C, protect from light, and store under inert gas.
Medchemexpress LLC Mal-amido-PEG4-NHS ester | 756525-99-2 | 99.2% | 513.50 | C22H31N3O11 | 100 MG
Mal-amido-PEG4-NHS ester is a PEG-based bifunctional linker containing a maleimide handle and an N-hydroxysuccinimide (NHS) ester. It provides a PEG4 spacer for flexibility and solubility and enables orthogonal conjugation to thiols and primary amines for use in PROTAC synthesis and bioconjugation applications.
- Provides a PEG4 spacer for increased solubility and flexible linker length.
- Maleimide group enables selective reaction with thiol groups for cysteine conjugation.
- NHS ester allows rapid coupling to primary amines under mild conditions.
- High purity suitable for synthetic and medicinal chemistry applications.
- Stable when stored at -20°C in solid form; follow solvent storage recommendations.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 10 MG
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker containing an amino terminus and an azide functional group. It is supplied as an oil and is intended for use in click-chemistry conjugations and the synthesis of antibody-drug conjugates; for research use only.
- Cleavable 11-unit PEG linker suitable for bioconjugation.
- Contains amino and azide functional groups for dual reactivity.
- Compatible with copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Supplied as an oil; store sealed away from moisture and light.
- Available in small laboratory pack sizes for research-scale use.