Crosslinking Reagents
Cayman Chemical DecnoIc AcId-d19 50mg
A fungal metabolite active against M tuberculosis H37Ra (MIC 6 3 g/ml) cytotoxic to BC1 human breast cancer cells (IC50 8 7 g/ml) inhibits the growth of multidrug-resistant isolates of E coli S aureus and E faecium at 15 g/disc induces cell death in HCT116 colorectal carcinoma cells
Cayman Chemical PseudomonIc AcId 50mg
An atypical antipsychotic a partial agonist at dopamine D2 D2L and D3 receptors (Kis 3 3 0 74 9 7 nM respectively) a partial agonist of 5-HT1A receptors (Ki 5 6 nM) and an inverse agonist of 5-HT2B receptors (Ki 0 36 nM) inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg
Sigma Aldrich Fine Chemicals Biosciences CfTM 647 succinimidyl este
Succinimidyl esters are amine reactive fluorescent dyes which function as probes in arrays studies and are used to label proteins.
Med Vet International Apoquel Chewable Tablets (Oclacitinib Chewable Tablet), 16mg, 250 Count
Apoquel Chewable (oclacitinib chewable tablet) is an oral chewable tablet that works differently from other skin allergy medications for dogs. It goes straight to the source to help relieve itch and inflammation at its core. Provides rapid relief from allergic dermatitis and has demonstrated to control allergic pruritus within 24 hours. Addresses the underlying cause of irritation and soothes allergic reactions For dogs older than 12 months of age to help lessen itch and inflammation due to allergic dermatitis Ideal for both short- or long-term treatment and can help to offer relief without many of the side effects associated with other medications
Cayman Chemical 3-keto UrsolIc AcId 50mg
An antitussive agent and ARPC2 inhibitor increases the latency to first cough and decreases the number of coughs during and after a citric acid aerosol challenge in a guinea pig model of cough at 27 mg/kg binds to ARPC2 and delays the initiation of actin polymerization in the presence of actin the Arp2/3 complex and VCA at 10 UM inhibits the migration and invasion of DLD-1 and AsPC-1 cancer cells from 1-10 UM reduces metastasis in an AsPC-1 mouse model of metastasis at 50 mg/kg
Cayman Chemical SulfosuccInImIdyl 32 BIot 50mg
An inhibitor of FTO (IC50 2.6 UM) reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s 0.8 and 1.5 UM respectively) increases m6A levels in isolated human bone marrow cells suppresses the proliferation of isolated human bone marrow cells and a panel of AML cells (IC50s 1.9-5.2 UM) delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model at 2 mg/kg
Cayman Chemical Sulfo-CynIn 5 5 10mg
An EAAT inhibitor inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s 96 and 31 UM respectively) inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki 0.6 UM) and by L-glutamate in EAAT5-expressing oocytes (Ki 2.5 UM) voltage-clamped at -60 mV intrathecal administration (7.5 and 15 Ug/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats
Cayman Chemical 3 5-DIcaffeoylquInIc AcId 50mg
An MT receptor antagonist (Kis 0.304 and 0.069 nM for MT1 and MT2 respectively in NIH3T3 cells expressing the human recombinant receptors) selective for MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 UM inhibits forskolin-induced cAMP accumulation (EC50s 0.79 and 1 nM respectively) in NIH3T3 cells expressing the MT1 or MT2 receptor respectively
Cayman Chemical Sulfo-CynIn 5 5 1mg
An analytical reference standard categorized as an alkaloid and MAOI a component of the hallucinogenic mixture ayahuasca that also contains DMT reduces certain symptoms of naloxone-induced opioid withdrawal in rats intended for use in analytical forensic applications
Cayman Chemical CarnosIc AcId 50mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids intended for research and forensic applications
Cayman Chemical RosmarInIc AcId 50mg
An internal standard for the quantification of cyclobenzaprine by GC- or LC-MS
Cayman Chemical DIsuccInImIdyl SulfoxIde 100mg
A cAMP-biased peptide GLP-1R agonist selectively induces cAMP accumulation overBarrestin recruitment (EC50s 0.018 and 1300 nM respectively) without inducing GLP-1R receptor internalization (EC50 >10000 nM) in cell-based assays using human GLP-1R reduces fasting and post-prandial blood glucose levels in db/db mice at 0.15 mg/kg reduces body weight and food intake in db/db mice at 0.05 mg/kg
Cayman Chemical DIsuccInImIdyl SulfoxIde 50mg
A non-prostaglandin EP2 receptor agonist selectively binds to human EP2 over EP1 EP3 and EP4 receptors (IC50s 10 >10000 >10000 and 5480 nM respectively) induces cAMP accumulation in HEK293 cells expressing human EP2 receptors (EC50 1.1 nM)
Cayman Chemical DocosahexaenoIc AcId 50mg
A sterol lipid and derivative of 5-androstenetriol cytotoxic to MDA-MB-231 PC3 HeLa and HT-29 cancer cells (IC50s 9 52.1 26.6 and 8 UM respectively) but not MRC-5 fibroblasts (IC50 >100 UM)
Cayman Chemical DIhomoLInolenIc AcId 50mg
A triantennary GalNAc ASGPR ligand has been used in the synthesis of siRNA-GalNAc conjUGates for RNA interference-mediated gene silencing in vitro and in mice