Protein Modification Reagents
Medchemexpress LLC m-PEG4-NH-DBCO | 2228857-36-9 | MFCD31654033 | ≥95.0% | C₂₈H₃₄N₂O₆ | 50 MG
m-PEG4-NH-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs utilize the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Click chemistry reagent
- Features a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Utilizes the ubiquitin-proteasome system
- Achieves selective degradation of target proteins
- For research use only
Medchemexpress LLC Cholesterol-PEG-maleimide | 95.1% | 2000 (average) | 25 MG
Cholesterol-PEG-maleimide (MW 2000) is a cholesterol-terminated polyethylene glycol derivative bearing a terminal maleimide for thiol-specific conjugation. Supplied as a solid, it is intended for incorporation into liposomes and nanoparticles to provide steric stabilization and enable covalent attachment of thiol-containing ligands for surface functionalization and targeted delivery applications.
- Provides steric stabilization to liposomes and nanoparticles.
- Maleimide group enables covalent conjugation to thiols via thioether bond.
- Average PEG molecular weight 2000; polydisperse polymeric material.
- High purity (~95.1%) suitable for formulation and conjugation studies.
- Soluble in DMSO up to 100 mg/mL; freshly opened DMSO recommended.
- Powder storage: -20°C; in solvent storage recommendations included.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
Medchemexpress LLC N-Mal-N-bis(PEG4-NH-Boc) | 2128735-27-1 | 97.0% | C37H66N4O15 | 100 MG
N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker, intended for research use only. This compound can be utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Suitable for PROTAC synthesis
- Supports the study of PROTACs that selectively degrade target proteins
- For research use only
- Exhibits in vitro biological activity
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 100mg
Collagenase from Clostridium histolyticumPurity: MW: | 9001-12-1 | MFCD00130830 | 100mg
Medchemexpress LLC Ethanol, 2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]- | 1807520-99-5 | 97.9% | C14H21N3O8 | 100 MG
DNP-PEG4-alcohol is a chemical compound commonly utilized as a PROTAC linker, playing a crucial role in proteolysis-targeting chimera (PROTAC) technology. This molecule is designed to facilitate targeted protein degradation by connecting a ligand that binds to a target protein with another ligand that recruits an E3 ubiquitin ligase. The PEG4 chain enhances solubility and provides conformational flexibility to optimize PROTAC efficacy.
- Acts as a PROTAC linker
- Facilitates targeted protein degradation
- Enhances solubility
- Provides conformational flexibility
ABclonal Technology MICU2 Rabbit pAb
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | MFCD11041099 | 98.8% | 207.27 | C9H21NO4 | 250 MG
m-PEG4-Amine is a polyethylene glycol (PEG) based bifunctional linker bearing a terminal primary amine. It is used as a short, flexible spacer in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates, facilitating amine-based conjugation reactions.
- Provides a PEG4 spacer (~4 ethylene glycol units)
- Terminal primary amine for amide or carbamate conjugation
- High purity (98.8%) suitable for research use
- Molecular weight 207.27 g/mol
- Typically supplied as a solid; common pack size 250 MG
eMolecules Mal-PEG6-NHS ester | Broadpharm | 1599472-25-9 | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696
Mal-PEG6-NHS ester | Broadpharm | 1599472-25-9 | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696
Medchemexpress LLC DSPE-Mal | 1360858-99-6 | 95.0% | 899.18 g/mol | C48H87N2O11P | 50 MG
DSPE-Mal is a maleimide-functional phospholipid used to introduce thiol-reactive maleimide groups into lipid assemblies and liposomes, enabling covalent coupling of thiol-containing ligands for targeted nanocarrier and surface functionalization applications.
- Maleimide-functionalized phospholipid for thiol-specific conjugation.
- Facilitates stable covalent coupling of thiol-containing ligands to lipid bilayers.
- Amphiphilic structure supports self-assembly into liposomes and vesicles.
- Useful for targeted drug delivery and nanocarrier surface modification.
- Offered in small research-scale quantities for formulation studies.
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 100 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Ligands target E3 ubiquitin ligase and target protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-OH | 2055041-39-7 | MFCD29918232 | 95.0% | 706.78 g·mol⁻¹ | C33H50N6O11 | 25 MG
Mal-PEG4-Val-Cit-PAB-OH is a cleavable four-unit polyethylene glycol (PEG) linker used for the synthesis of antibody-drug conjugates (ADCs). It features a maleimide group for thiol conjugation and a Val-Cit-PAB cleavable spacer that enables intracellular payload release upon proteolysis.
- Cleavable Val-Cit-PAB spacer for protease-triggered payload release.
- Four-unit PEG spacer to increase solubility and reduce aggregation.
- Maleimide functional group for efficient thiol conjugation.
- Designed for antibody-drug conjugate synthesis and research applications.
Medchemexpress LLC Bcn-PEG3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 25 MG
BCN-PEG3-Biotin is a biotinylated, non-cleavable PEG3 antibody-drug conjugate linker containing a BCN strained alkyne for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry. It is supplied as an off-white to light yellow solid for research use in bioconjugation, ADC synthesis, and affinity-based labeling.
- Non-cleavable PEG3 linker with BCN for copper-free click chemistry.
- Biotin tag enables streptavidin-based capture and detection.
- Off-white to light yellow solid, soluble in DMSO at 100 mg/mL.
- Purity 95.0% as specified by the manufacturer.
- Store powder at -20°C; prepared solutions stable at -80°C (6 months) or -20°C (1 month).
- Available in milligram quantities including 25 MG.