Protein Modification Reagents
![eMolecules Biotin-PEG-Thiol, MW 2,000 | Broadpharm |347.490 | C14H25N3O3S2 | 0.000 | SCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 627958177](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475698.JPG-250.jpg)
eMolecules Biotin-PEG-Thiol, MW 2,000 | Broadpharm |347.490 | C14H25N3O3S2 | 0.000 | SCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 627958177
Biotin-PEG-Thiol, MW 2,000 | Broadpharm |347.490 | C14H25N3O3S2 | 0.000 | SCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 627958177
![eMolecules N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475851.JPG-250.jpg)
eMolecules N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873
N-bis(Azido-PEG10)-N-(PEG10-t-butyl ester) | Broadpharm |1604.926 | C71H141N7O32 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 599128873
eMolecules DBCO-PEG4-PFP ester | Broadpharm |718.674 | C36H35F5N2O8 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 411413975
DBCO-PEG4-PFP ester | Broadpharm |718.674 | C36H35F5N2O8 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 411413975
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g·mol⁻¹ | C43H83N4O9P | 25 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent in biochemical and nanotechnology research. It enables both copper-catalyzed and strain-promoted azide-alkyne cycloadditions for reliable conjugation of biomolecules, surface modification, and lipid nanoparticle functionalization.
- Azide-functionalized phospholipid enabling click chemistry conjugation.
- Compatible with CuAAC and SPAAC reaction conditions.
- Suitable for nanoparticle and surface functionalization applications.
- White to off-white solid with standard storage requirements.
- Soluble in DMSO with warming and sonication for formulation.
- High purity (~96.4%) appropriate for research use.
![eMolecules 2639395-40-5 | PTAD-PEG4-Azide | Broadpharm539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183599.JPG-250.jpg)
eMolecules 2639395-40-5 | PTAD-PEG4-Azide | Broadpharm539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753
PTAD-PEG4-Azide | Broadpharm | 2639395-40-5539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753
Medchemexpress LLC DSPE-PEG-COOH | 98.1% | 5000 (average) | 10 MG
DSPE-PEG-COOH (MW 5000) is a PEGylated phospholipid used to modify liposome and nanoparticle surfaces to improve solubility, circulation time, and tissue targeting of poorly soluble drugs.
- PEGylated phospholipid with an average molecular weight of 5,000 Da.
- Carboxylic acid terminal group enables covalent conjugation and surface functionalization.
- Enhances colloidal stability and circulation half-life in delivery systems.
- Soluble in DMSO at approximately 100 mg/mL with sonication; hygroscopic DMSO may affect solubility.
- Appearance: white to off-white solid.
- Recommended storage: sealed at -20°C; in solvent store at -80°C for long-term (up to 6 months).
- Reported purity: 98.1%.
Cayman Chemical PEG 2000-C-DMG 10mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
Medchemexpress LLC m-PEG5-succinimidyl carbonate | 1058691-00-1 | 98.0% | 393.39 g/mol | C16H27NO10 | 25 MG
m-PEG5-succinimidyl carbonate is a monomethoxy polyethylene glycol (PEG) linker with five ethylene glycol units terminated as a succinimidyl carbonate active ester. It is supplied as a reactive linker for conjugation to primary amines in bioconjugation workflows.
- Non-cleavable 5-unit PEG spacer for conjugation.
- Activated succinimidyl carbonate for efficient amine coupling.
- Suitable for ADC and PROTAC synthesis applications.
- Appearance: colorless to light yellow liquid; supplied in small mg quantities for research use.
eMolecules 1343476-41-4 | Acid-PEG5-NHS ester | Broadpharm | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
Acid-PEG5-NHS ester | Broadpharm | 1343476-41-4 | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
eMolecules 1426164-53-5 | Bis-Mal-Lysine-PEG4-TFP ester | Broadpharm | MFCD28385461 | 843.783 | C37H45F4N5O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)C(CCCCNC(=O)CCN2C(=O)C=CC2=O)NC(=O)CCN2C(=O)C=CC2=O)c1F | 100mg | 272383796
Bis-Mal-Lysine-PEG4-TFP ester | Broadpharm | 1426164-53-5 | MFCD28385461 | 843.783 | C37H45F4N5O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)C(CCCCNC(=O)CCN2C(=O)C=CC2=O)NC(=O)CCN2C(=O)C=CC2=O)c1F | 100mg | 272383796
Medchemexpress LLC 4-Arm-PEG-OH (MW 20000) | 98.0% | 20000 | 5 MG
4-Arm-PEG-OH (MW 20000) is a PEG derivative with a four-arm structure and a hydroxyl (OH) functional group. It reacts with functional groups on biomolecules (such as proteins, peptides, antibodies, etc.) through hydroxyl groups and can be used for drug delivery.
- PEG derivative with a four-arm structure
- Hydroxyl (OH) functional group
- Reacts with functional groups on biomolecules
- Suitable for drug delivery
Medchemexpress LLC N3-PEG2-C2-NHS ester | 1312309-64-0 | MFCD20926376 | ≥98.0% | 300.27 | C11H16N4O6 | 250 MG
N3-PEG2-C2-NHS ester is an azide-functionalized PEG2 NHS ester linker used for bioconjugation and the synthesis of antibody-drug conjugates. The molecule contains an NHS ester for coupling to primary amines and an azide group enabling click chemistry (copper-catalyzed azide-alkyne cycloaddition and strain-promoted cycloaddition). It is provided as a high-purity liquid and is soluble in DMSO for research-scale conjugation.
- Azide-functionalized PEG2 linker for click chemistry
- NHS ester for efficient amine coupling
- High purity (≥98.0%) for reliable conjugation
- Soluble in DMSO (approx. 100 mg/mL) for stock solutions
- Stable when stored dry at -20°C for extended periods
Medchemexpress LLC Mal-PEG2-oxyamine | 1146245-73-9 | MFCD00209801 | 95.0% | 244.24 g·mol⁻¹ | C10H16N2O5 | 5 MG
Mal-PEG2-oxyamine is a PEG-based bifunctional linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It contains a maleimide group and an oxyamine moiety separated by a PEG2 spacer, enabling thiol-maleimide coupling and oxime ligation for efficient bioconjugation. The free base can be prone to instability; a TFA salt is available to improve stability.
- Bifunctional maleimide and oxyamine reactive groups.
- PEG2 spacer provides flexibility and improved solubility.
- Compatible with thiol conjugation and oxime ligation chemistries.
- Offered as a small-scale reagent (e.g., 5 mg) with reported purity around 95%.