Protein Modification Reagents
![eMolecules Medchem Express / Pomalidomide-PEG2-COOH / 25mg / 633697027 / HY-131872 / / 2140807-17-4 / [null] / 433.417 / C20H23N3O8](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502471426.JPG-250.jpg)
eMolecules Medchem Express / Pomalidomide-PEG2-COOH / 25mg / 633697027 / HY-131872 / / 2140807-17-4 / [null] / 433.417 / C20H23N3O8
Medchem Express / Pomalidomide-PEG2-COOH / 25mg / 633697027 / HY-131872 / / 2140807-17-4 / [null] / 433.417 / C20H23N3O8
![Medchemexpress LLC Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]- | 134978-97-5 | 163.17 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]- | 134978-97-5 | 163.17 | 5 G
H2N-PEG2-CH2COOH is a PEG-based PROTAC linker, appearing as a white to yellow solid. This compound can be utilized in the synthesis of PROTACs, which are molecular tools composed of two distinct ligands joined by a linker. One ligand binds to an E3 ubiquitin ligase, and the other targets a protein of interest, allowing PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- White to yellow solid appearance
- High purity (99.87%)
Vector Biolabs S-phase kinase-associated protein 2 (p45) Adenovirus (Ad-SKP2)
Cyclin A-Cdk2 kinase activity is essential for progression of the cell through S phase. Skp1 p19 and Skp2 p45 are elements of the cyclin A-Cdk2 S phase kinase. The binding of p19 to cyclin A-Cdk2 is p45-dependent, and levels of p45 are substantially increased in transformed cells. Thus, the modulation of Skp2 p45 expression may result in changes in cell cycle control that contribute to the process of cell transformation.
Cayman Chemical N 1-Carboxyethyl-L-lysIn 5mg
An advanced glycation end product; protein bound, but not free CEL, binds to RAGE; elevated in the lens of diabetic patients with cataract; decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner at 1 mM
Medchemexpress LLC S-(2-carboxyethyl)-L-cysteine | 4033-46-9 | MFCD03424208 | 98.6% | 193.22 g·mol⁻1 | C6H11NO4S | 10 MG
S-(2-Carboxyethyl)-L-cysteine is an amino acid-derived research reagent provided as a solid for biochemical and pharmacological studies that require a cysteine derivative. The compound is characterized with analytical data to support research use and is offered in small quantities for laboratory experiments.
- High purity: 98.6%.
- Chemical formula: C6H11NO4S.
- Molecular weight: 193.22 g·mol⁻1.
- Physical form: solid; soluble in water at 5 mg/mL with ultrasonic assistance.
- Available sizes: includes 10 mg and 25 mg; larger sizes available by quote.
- Supporting documents: data sheet, COA, SDS, HNMR, RP-HPLC, MS.
Cayman Chemical TCEP-bIotIn 500ug
An affinity probe for protein lysine crotonylation; addition of the TCEP moiety to crotonylated lysine residues results in adduct formation that allows for detection or immobilization of crotonylated proteins through interaction with the biotin ligand; has been used in the detection and isolation of crotonylated histones in HEK293 cells
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.
- Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
- Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
- Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
- Arrests both HCC827 and H1975 cell lines at G1 phase.