Protein Modification Reagents
![eMolecules 721431-18-1 | 3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1767738.jpg-250.jpg)
eMolecules 721431-18-1 | 3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416
3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | 721431-18-1 | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416
Chemscene ChemScene | N3-PEG4-C2-Pfp ester | 250MG | CS-0105087 | 0.97 | 1353012-00-6| MFCD20926373 | 457.35
ChemScene | N3-PEG4-C2-Pfp ester | 250MG | CS-0105087 | 0.97 | 1353012-00-6| MFCD20926373 | 457.35
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 25g | 844822186
Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 25g | 844822186
Medchemexpress LLC Bromoacetamido-PEG5-azide | 1415800-37-1 | 95.5% | C14H27BrN4O6 | 10MG
Bromoacetamido-PEG5-azide is a heterobifunctional PEG-based linker used for PROTAC assembly and bioconjugation. It combines a bromoacetamido electrophile, which undergoes nucleophilic substitution with thiols and other nucleophiles, with an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC). The PEG5 spacer imparts flexibility and improved solubility, and the material is supplied at approximately 95.5% purity for research applications.
- Heterobifunctional design enables sequential orthogonal reactions.
- Bromoacetamido group reacts selectively with nucleophiles, such as thiols.
- Azide moiety compatible with CuAAC and SPAAC click chemistries.
- PEG5 spacer enhances solubility and conformational flexibility.
- Reported high purity suitable for research and synthesis workflows.
- Available in research-scale quantities for method development.
Medchemexpress LLC Dota-peg5-c6-dbco | 00-00-0 | 96.3% | C49H71N7O14 | 10MG
DOTA-PEG5-C6-DBCO is a heterobifunctional PEG-based linker that combines a DOTA chelator with a DBCO moiety for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC). Supplied as a high-purity solid, it is designed for bioconjugation, PROTAC linker synthesis, and preparation of radiometal-labeled conjugates where chelation and bioorthogonal coupling are required.
- Heterobifunctional linker with DOTA chelator and DBCO reactive group.
- Enables copper-free SPAAC click conjugation to azide-functionalized molecules.
- Suitable for radiometal chelation and preparation of labeled conjugates.
- High purity (96.3%).
- Solid powder format with recommended storage at -20°C.
- Available in small batch sizes (5 mg-200 mg, larger quantities by quote).
Medchemexpress LLC Mal-PEG2-oxyamine TFA | 00-00-0 | MFCD00209801 | 96.5% | C12H17F3N2O7 | 10MG
Mal-PEG2-oxyamine TFA is a PEG-based bifunctional linker supplied as the trifluoroacetic acid (TFA) salt for use in PROTAC synthesis and other bioconjugation applications. It combines a maleimide reactive group with an oxyamine functional handle, and a short PEG2 spacer to enhance solubility and flexibility.
- Bifunctional linker enabling thiol and carbonyl conjugation.
- Maleimide permits rapid, thiol-selective coupling under mild conditions.
- Oxyamine enables chemoselective oxime ligation to aldehydes and ketones.
- PEG2 spacer increases aqueous solubility and reduces steric hindrance.
- Provided as TFA salt to improve stability and handling.
- High purity suitable for research and synthetic workflows.
STEMCELL Technologies Collagenase Type I, Size: 100 mg
Collagenase is a protease consisting of a single polypeptide chain approximately 1,000 amino acid residues in length. Collagenase is capable of digesting native collagen fibrils commonly found in connective tissues and therefore is frequently used for tissue dissociation. Collagenase Type I contains the activity of several proteases, including collagenase, caseinase, clostripain, and trypsin. Collagenase Type I has been used for the digestion of human tissues such as intestine (Barthel et al.), mammary glands (Huss & Kratz), and prostate (Le et al.), as well as specific cell types such as endothelial cells (Ganguly et al.) and dorsal root ganglion cells (Dib-Hajj et al.).
Medchemexpress LLC Endo-BCN-PEG2-C2-NHS ester | 2243565-12-8 | 95.0% | C22H30N2O8 | 10MG
endo-BCN-PEG2-C2-NHS ester is a PEG-based bifunctional linker for PROTAC construction and bioconjugation. It combines a strained endo-bicyclononyne (BCN) for copper-free click chemistry with an N-hydroxysuccinimide (NHS) ester for selective amine coupling, enabling efficient assembly of bifunctional molecules and protein labeling.
- Contains endo-bicyclononyne (BCN) for strain-promoted azide-alkyne cycloaddition
- Includes an N-hydroxysuccinimide (NHS) ester for rapid amine conjugation
- Incorporates a PEG2 spacer to improve solubility and reduce steric hindrance
- Suitable for PROTAC linker synthesis and bioconjugation workflows
- Molecular formula C22H30N2O8 and molecular weight 450.48 g/mol