Cytokines and Receptors Reagents and Kits
Raybiotech Inc Quantibody Human Adhesion Molecule Array 1 Kit.
Detects detects 17 human cell adhesion molecules. Suitable for all liquid sample types. Quantitative, Sandwich-based, Glass Slide Antibody Array. Simultaneous quantitative measurement of multiple proteins in a wide variety of sample types. Quantibody combines the high specificity and sensitivity of ELISA with the high throughput of the glass chip-based array. Less sample, more data: only 50 ul of sample is needed for quantification of up to 40 cytokines. Proteins detected: ALCAM (CD166), BCAM, CEACAM-1, E-Cadherin, TROP1 (EpCAM), E-Selectin, ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), L-Selectin (CD62L), NCAM-1 (CD56), NrCAM, P-Cadherin, P-Selectin, PECAM-1 (CD31), VCAM-1 (CD106), VE-Cadherin (CDH5)
Raybiotech Inc Quantibody Human Adhesion Molecule Array 1 Kit.
Detects detects 17 human cell adhesion molecules. Suitable for all liquid sample types. Quantitative, Sandwich-based, Glass Slide Antibody Array. Simultaneous quantitative measurement of multiple proteins in a wide variety of sample types. Quantibody combines the high specificity and sensitivity of ELISA with the high throughput of the glass chip-based array. Less sample, more data: only 50 ul of sample is needed for quantification of up to 40 cytokines. Proteins detected: ALCAM (CD166), BCAM, CEACAM-1, E-Cadherin, TROP1 (EpCAM), E-Selectin, ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), L-Selectin (CD62L), NCAM-1 (CD56), NrCAM, P-Cadherin, P-Selectin, PECAM-1 (CD31), VCAM-1 (CD106), VE-Cadherin (CDH5)
Raybiotech Inc Quantibody Human Immune Checkpoint Molecule Array 1 Kit.
Detects 10 Human Immune Checkpoint Molecules. Suitable for all liquid sample types. Quantitative, Sandwich-based, Glass Slide Antibody Array. Simultaneous quantitative measurement of multiple proteins in a wide variety of sample types. Quantibody combines the high specificity and sensitivity of ELISA with the high throughput of the glass chip-based array. Less sample, more data: only 50 ul of sample is needed for quantification of up to 40 cytokines. Proteins detected: CD80 (B7-1), CD86 (B7-2), B7-H1 (CD274), B7-H2 (ICOS Ligand), B7-H3 (CD276), CD28, CTLA-4 (CD152), ICOS, PD-1, PD-L2 (B7-DC),
Raybiotech Inc Quantibody Human Immune Checkpoint Molecule Array 1 Kit.
Detects 10 Human Immune Checkpoint Molecules. Suitable for all liquid sample types. Quantitative, Sandwich-based, Glass Slide Antibody Array. Simultaneous quantitative measurement of multiple proteins in a wide variety of sample types. Quantibody combines the high specificity and sensitivity of ELISA with the high throughput of the glass chip-based array. Less sample, more data: only 50 ul of sample is needed for quantification of up to 40 cytokines. Proteins detected: CD80 (B7-1), CD86 (B7-2), B7-H1 (CD274), B7-H2 (ICOS Ligand), B7-H3 (CD276), CD28, CTLA-4 (CD152), ICOS, PD-1, PD-L2 (B7-DC),
Genscript Corporation IFN-λ1, Human
IL-28A, IL-28B, and IL-29, also named interferon-λ2 (IFN-λ2), IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λR1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.
Genscript Corporation IFN-λ1, Human
IL-28A, IL-28B, and IL-29, also named interferon-λ2 (IFN-λ2), IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λR1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.
Sigma Aldrich Fine Chemicals Biosciences SMCTM Human IL 1alpha High
The SMC(TM) human IL-1alpha High Sensitivity Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format.Assay protocols are similar to existing sandwich ELISA methods with two key differences1) Elution buffer disrupts the sandwich separating the labeled detection antibody for quantification.2)The Erenna and SMCxPRO(TM) immunoassay systems detect analytes using Single Molecule Counting (SMC(TM)) technology.
Medchemexpress LLC AITRL/TNFSF18 Mouse 50ug
AITRL a type II transmembrane protein is a ligand for glucocorticoid-induced TNFR-related protein (GITR) When AITRL binds to GITR GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions GITR/AITRL interaction plays a role in the pathogenesis of tumor inflammation as well as autoimmune diseases[1] Besides AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1 ICAM-1)[2] AITRL/TNFSF18 Protein Mouse is a recombinant mouse AITRL (T47-S173) without tag which is expressed in E coli
Genscript Corporation IL-16, Human
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
Genscript Corporation IL-16, Human
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
Genscript Corporation IL-16, Human
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
Genscript Corporation Benz-Neburase™, tag-free
The Benz-Neburase is a genetically engineered endonuclease from Serratia marcescens used as a DNA eraser in the purification processes of biological molecules. The enzyme cleaves all forms of DNA and RNA into smaller nucleotides of around 5-8 base pairs. Benz-Neburase requires divalent cation, preferably Mg2+ for activity, displays a broad pH tolerance, ranging from pH 6 to pH10, with an optimal pH of 8-8.5, and has a wide temperature tolerance, ranging from 35℃ to 44℃. The nuclease is a physiologic homodimer and functions more progressively than the monomer. Two disulfide bonds in the nuclease are crucial to its activity and stability. The enzyme is active in a broad range of conditions and is free of proteolytic activity. This makes the enzyme especially useful for biopharmaceutical applications with contaminating DNA residue, such as lysed host cells in viral vector manufacturing processes.
Meso Scale Discovery MSD GOLD SULFO-TAG NHS-Ester 150 nmol
MSD GOLD SULFO-TAG NHS-Ester is an N-hydroxysuccinimide ester which readily couples to primary amine groups of proteins. SULFO-TAG conjugated proteins are used as detection reagents in MSD immunoassays. The conjugates are stable, may be used at low concentrations, have low non-specific binding, and result in highly sensitive detection. The exceptional performance characteristics and simple conjugation procedure of SULFO-TAG NHS-Ester make it the product of choice for molecules that contain primary amines (e.g., lysine in proteins). MSD GOLD SULFO-TAG NHS-Ester has been developed through rigorous multi-lot testing for reproducibility and precision. Exceptional intra-lot and inter-lot consistency of the reagent make it ideal for customers working in validated environments or conducting longitudinal studies that require high performance and reproducibility.
Meso Scale Discovery V-PLEX HUMAN IL-17A KIT
Human interleukin-17A (IL-17A), also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8), is a glycosylated 17.5 kDa homodimer protein with two disulfide bonds. It induces stromal cells to produce proinflammatory and hematopoietic cytokines, and it enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. IL-17A is a positive regulator of IL-23 production and is a key component of the Th17 pathway. IL-17A can dimerize with IL-17F. The receptor for the IL-17A, IL-17F, and IL-17A/IL-17F hetereodimer consists of IL-17RA and IL-17RC. IL-17A is involved in human rhinovirus infection and Sjogrens syndrome. The Human IL-17A Kit provides assay-specific components for the quantitative determination of endogenous IL-17A in human urine, serum, plasma, and cell culture supernatants
STEMCELL Technologies Human Recombinant IL-1 beta, ACF, Size: 100 µg
Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
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