Immunohistochemistry Kits and Reagents
Biotium FOXP3(FXP3/197), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are availabl
Biotium Cytokeratin 8 (KRT8)(KRT8/2115), Biotin conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ('ring-like, perinuclear') from ductal ('peripheral-predominant')
Electron Microscopy Sciences IHC Retriever Section Block 125 ML
A new class of blocking solutions based on chemically modified and fragmented ultra-pure casein. Effectively reduces unwanted binding of primary antibody and conjugates you use to charged surface of the slide and tissue section. Greatly reduces non-specific binding while preserving the specific reaction, by saturating potential non-specific protein-protein interactions. Moreover, in contrast to BSA-based, IgGm casein or serum - based blocking solutions there is no interaction of specific antibody and blocking protein itself. or oth Is not comparable to other commercially available or home-made blocking solutions. Recommended for research and diagnostic pathology, especially for retrieved sections and polyclonal antibodies.
ABclonal Technology NDUFA4L2 Rabbit pAb
Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex IV.
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Multiplex Human Phospho-STAT6 (Tyr641 & total) Detection Kit, Control Lysate
AlphaLISA SureFire Ultra Multiplex Human Phospho-STAT6 (Tyr641 & total) Detection Kit, Control Lysate
Abcam Tissue Clearing Reagent 1 - hydrophobic, 30ML
Tissue Clearing Reagent 1 ab243300 is part of our range of tissue clearing reagents and products that enable you to set up tissue clearing easily and quickly.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology ALDH1A2 Rabbit mAb
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
STEMCELL Technologies MegaCult™-C Staining Kit for CFU-Mk, Size: 1 Kit
Stain fixed and dehydrated CFU-Mk colonies cultured in MegaCult™-C collagen-based medium using the reagents included in MegaCult™-C Staining Kit for CFU-Mk. • MegaCult™-C Primary Antibody• MegaCult™-C Control Antibody• MegaCult™-C Human Serum• MegaCult™-C Alkaline Phosphatase Substrate Tablets• MegaCult™-C Biotin-Conjugated Goat Anti-Mouse IgG• MegaCult™-C Evans Blue Stain• MegaCult™-C 10% BSAMegakaryocytes and platelets expressing the glycoprotein IIb/IIIa are stained with anti-human CD41 antibody and an alkaline phosphatase detection system. The kit is also suitable for the detection of bipotential erythroid-megakaryocyte progenitor cells (BFU-E/Mk).For your convenience, the kit components are also available for purchase individually, upon request.
Biotium CD30(CD30/412), CF594 conjugate, 0.1mg/mL
Recognizes a single chain glycoprotein of 105/120 kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90 kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120 kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fl
Medchemexpress LLC Citarinostat- Ready For Recons | HY-15994-10MM 1ML IN DMSO
Citarinostat- Ready For Recons
Biotium Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16, CF740 conjugate, 0.1mg/mL
This antibody recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes of
Rockland Immunochemicals Fluorescent Activated Cell Sorting (FACS) and Immunofluorescence (IF) Staining Buffer with Goat Serum - MB-088-0500
Fluorescent Activated Cell Sorting (FACS) and Immunofluorescence (IF) staining buffer is a diluent buffer optimized for use in flow cytometry and immunofluorescence assay of viable and/or fixed cells. FACS and IF staining, washing buffer contains 2% goat serum as carrier and stabilizer to reduce non-specific binding of antibodies and fluorochrome reagents to targets cells. Metabolic inhibitors and NaN3 are also included in the flow cytometry and immunofluorescence buffer to prevent patching, capping of surface antigen and bacterial growth.
BIOGEMS INTERNATIONAL INC Transcription Factor Fixation/Permeabilization Concentrate
The Transcription Factor Fixation/Permeabilization solution can be used with the relevant antibodies to stain for transcription factors such as Foxp3 and intranuclear staining of cytokines, chemokines, and nuclear proteins. The concentrated solution should be used with the Transcription Factor Fixation/Permeabilization Diluent (cat#92555-00) and Permeabilization Buffer (cat# 92110-00).
Biotium Myogenin(MGN185), CF594 conjugate, 0.1mg/mL
Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes
Cayman Chemical YTHDC2 PolycLNal ANTIBDY 500ug
Immunogen: Full-length recombinant human YTHDC2 protein • Host: Rabbit • Species Reactivity: (+) Human • Applications: IF, IHC, and WB • MW = 160 kDa