Mammalian ORFs
American Research Products Inc Mouse Proto oncogene Wnt 1 WN
Mouse Proto-oncogene Wnt-1 (WNT1) ELISA kit from CUSABIO Detection Range 18 75 pg/mL-1200 pg/mL Sensitivity 4 68 pg/mL Sample serum plasma tissue homogenates Method Sandwich
ABclonal Technology p-LATS1-T1079-LATS2-T1041
The protein encoded by this gene is a putative serine threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis The protein is phosphorylated in a cell-cycle dependent manner with late prophase phosphorylation remaining through metaphase The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity indicating a role as a negative regulator of CDC2 cyclin A In addition the C-terminal kinase domain binds to its own N-terminal region suggesting potential negative regulation through interference with complex formation via intramolecular binding Biochemical and genetic data suggest a role as a tumor suppressor This is supported by studies in knockout mice showing development of soft-tissue sarcomas ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments
ABclonal Technology KO Validated NRF2 Rabbit mAb
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals Multiple transcript variants encoding different isoforms have been characterized for this gene
ABclonal Technology p-LATS1-T1079-LATS2-T1041
The protein encoded by this gene is a putative serine threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis The protein is phosphorylated in a cell-cycle dependent manner with late prophase phosphorylation remaining through metaphase The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity indicating a role as a negative regulator of CDC2 cyclin A In addition the C-terminal kinase domain binds to its own N-terminal region suggesting potential negative regulation through interference with complex formation via intramolecular binding Biochemical and genetic data suggest a role as a tumor suppressor This is supported by studies in knockout mice showing development of soft-tissue sarcomas ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments
ABclonal Technology LATS2 Rabbit pAb
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
ACROBiosystems Human Glypican 3 (GPC3) R355A,R358A Protein, Fc Tag, HEK293, 100 μg
Recombinant human Glypican-3 (GPC3) R355A,R358A is an Fc-tagged, glycosylated protein expressed in HEK293 cells, provided purified for use in binding studies, assay development, and biochemical characterization.
- Mutations: R355A and R358A.
- Tag: Human IgG1 Fc at the C-terminus.
- Expression system: HEK293 (human 293 cells).
- Amino acid range: Gln 25 - His 559.
- Calculated molecular weight: 87.1 kDa; glycosylated protein migrates ~230 kDa on non-reducing SDS-PAGE and is ~170-210 kDa by SEC-MALS.
- Purity: >95% by SDS-PAGE; >90% by SEC-MALS.
- Available sizes: 100 μg and 1 mg.
Genscript Corporation GPC3/Glypican 3Biotin His
Glypican-3 is a protein which is encoded by the GPC3 gene in humans The protein core of GPC3 consists of two subunits where the N-terminal subunit has a size of 40 kDa and the C-terminal subunit is 30 kDa Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers Several therapeutic anti-GPC3 antibodies have been developed
ABclonal Technology LATS2 Rabbit pAb
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
OriGene PVRL4 (NECTIN4) (NM_030916) Human Over-expression Lysate, 100ug
Components:1 vial of 100 µg gene specific transient over-expression cell lysate in RIPA buffer1 vial of 100 µg whole HEK293T cell lysate in RIPA buffer1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromophenol blue, 100mM DTT)