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Translatable codon sequences collected from mammalian DNA and RNA. Open reading frames (ORFs) can be used for a variety of molecular applications including gene prediction and identification of protein-coding or functional RNA-coding regions in a DNA sequence.
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This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms.
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This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Glypican-3 is a protein which is encoded by the GPC3 gene in humans The protein core of GPC3 consists of two subunits where the N-terminal subunit has a size of 40 kDa and the C-terminal subunit is 30 kDa Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers Several therapeutic anti-GPC3 antibodies have been developed
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