Non-isotopic Labeling Reagents and Kits
Enzo Life Sciences PF-356231 (5mg). CAS: 766536-21-4
Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml). Long Term Storage: -20°C.
Dojindo Molecular Technologies Inc ICG Labeling Kit-NH2, is used for preparation of Indocyanin green-labeled antibody for near-infrared fluorescence imaging, suitable wavelength for in vivo imaging with more than 90% recovery rate.
ICG Labeling Kit - NH2 is primarily used for the preparation of ICG-labeled antibodies for near-infrared fluorescence imaging. The excitation and emission wavelength of the ICG-labeled proteins are 774 nm and 805 nm, respectively. Thus, ICG are suitable materials for in vivo imaging. NH2 Reactive ICG, a component of this kit, has a succinimidyl ester group, and can easily make a covalent bond with an amino group of the target protein without any activation process. Filtration Tube included in this kit is used for sample protein in removing small molecules such as amine compounds that interfere with a labeling reaction. The labeling process is very simple. Just add the NH2-Reactive ICG to protein solution(50-200 UG protein/sample) on a filter membrane, and incubate at 37°C for 10 min. Excess ICG molecules can be removed by a filtration tube.
Enzo Life Sciences BIOARRAY™ Terminal labeling kit with biotin-ddUTP for DNA probe array assays (25Reactions)
The BIOARRAY™ 3’-OH Terminal Labeling System is the gold standard end-labeling system for use with Affymetrix DNA SNP, Resequencing and Prokaryotic microarrays. The BIOARRAY™ Terminal Labeling Kit with Biotin-ddUTP has been developed for DNA probe array assays. This method uses Bio-ddUTP and terminal deoxynucleotide transferase to catalyze the addition of a single biotin-ddUMP to the 3’-OH terminus of an amplified and fragmented target DNA molecule. A standard reaction will label up to 100 picomoles (equivalent to 1µg of a 30-nucleotide sequence). When DNA fragments are labeled at the 3’-OH terminus, the sequence bias that occurs with either nick translation or random priming is eliminated.
Medchemexpress LLC 2-(4-methylphenyl)sulfonyl-5-nitrofuran | 343351-67-7 | MFCD01925132 | 99.9% | C11H9NO5S | 10MG
NSC697923 is a research-grade small-molecule inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) used to block Ubc13-mediated polyubiquitination in biochemical and cellular studies. It is supplied as a white to light-yellow solid with high purity, exhibits good solubility in DMSO, and is stable when stored as a powder at recommended cold temperatures.
- Selective inhibition of UBE2N (Ubc13) activity in vitro and in cells.
- High purity suitable for biochemical and cellular assays.
- White to light-yellow solid with consistent appearance.
- High solubility in DMSO for preparation of concentrated stock solutions.
- Formulation guidance provided for in vivo administration.
- Stable as a powder under recommended cold storage conditions.
Medchemexpress LLC Lsp-249 | 1801253-04-2 | MFCD32671321 | 99.1% | 431.92 g/mol | C24H22ClN5O | 5 MG
LSP-249 (CAS 1801253-04-2) is a small-molecule plasma kallikrein inhibitor described in patent literature and provided for preclinical research. It has been reported to show sub-micromolar activity in cell-based assays and is supplied as a well-characterized, high-purity solid for biochemical and cellular testing. Typical packaging is in milligram quantities and material should be handled and stored according to the safety data sheet.
- High purity suitable for analytical and biological studies.
- Demonstrated plasma kallikrein inhibitory activity in cell assays.
- Supplied as a solid, white to light yellow, for easy handling.
- Available in small milligram packs for preclinical research.
- Stable under recommended storage for long-term use when stored per SDS.
- Well-characterized chemical identity: C24H22ClN5O, 431.92 g/mol.
Enzo Life Sciences (R)-BI-2536 (10mg). CAS: 755038-02-9
Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC50 values below 1 µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases Plk2 and Plk3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (21mg/ml) or ethanol (100mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences (R)-BI-2536 (5mg). CAS: 755038-02-9
Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC50 values below 1 µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases Plk2 and Plk3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (21mg/ml) or ethanol (100mg/ml). Long Term Storage: -20°C.