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Reagents, kits, and instruments for use during the extraction of proteins from bacteria, cultured mammalian cells and tissues, insect cells, yeast cultures, flowering plants, etc. Products include lysis buffers, master mixes, and solubilizing solutions.
MW 399.5 Da, Purity >98%. Inhibitor of nuclear protein pirin. Inhibits the interaction between Bcl3 oncoprotein and pirin. Melanoma cell migration inhibitor.
Protein. Human FasL aa 139-281 is fused at the N-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse Fas. Purity >95% SDS-PAGE. Fc humanFasL, Soluble human is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development.
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A selective nonpeptide CCR1 antagonist that can displace the endogenous CCR1 ligands MIP-1a RANTES and MCP-3 with Ki values of 1 2 8 and 5 5 nM respectively reduces chemotaxis of inflammatory cells in models of multiple sclerosis sepsis rheumatoid arthritis and lupus nephritis
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