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An Mps1 inhibitor (IC50 0.34 nM) inhibits nocodazole-induced metaphase arrest in HeLa cells (IC50 56 nM) inhibits proliferation in a panel of 86 cancer cell lines (median IC50 6.7 nM) reduces tumor area in a cisplatin-resistant A2780/CP70 ovarian cancer mouse xenograft model at 2.5 mg/kg
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