General Cell Based Assays
Eurofins Discoverx PathHunter Human TNF alpha (IL17RD/TNFR2) Dimerization Cell-Based Assay Kit (U2OS)
The PathHunter Human TNF alpha (IL17RD/TNFR2) Stable Cell Line Dimerization Assay (U2OS) measures ligand-induced dimerization of IL17RD/TNFR2 . This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical EstradIol 3 DGlucuronIde 10mg
A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM)
Eurofins Discoverx PathHunter Human HRH2 (H2) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human HRH2 (H2) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure HRH2 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human MCP-1 (CCR2) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human MCP-1 (CCR2) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure CCR2 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human NMU1R β-Arrestin Cell-Based Assay Kit (U2OS)
The PathHunter Human NMU1R β-Arrestin Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure NMU1R (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical D-Fructose-1 6-bIsphosphate 5g
An intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis
ILEX LIFE SCIENCES LLC QuickZyme Sensitive Tissue Collagen Assay Kit, 2 x 96 Assays, 96-well plate format, colorimetric assay for low level collagen analysis (tissue, tissue homogenates samples)
QuickZyme Sensitive Tissue Collagen Assay Kit enables collagen analysis in small tissue samples with low collagen levels. The assay is based on quantitative colorimetric determination of hydroxyproline residues, obtained by acid hydrolysis of collagen. The assay allows quantitative measurement of all types of collagen, species independent. The only hydroxyproline-based assay which shows no matrix effect and no need for further dilution of hydrolysate. No drying of hydrolysate is needed, resulting in a fast and easy (96-well plate format) assay. Application: tissues with low collagen/hydroxyproline content (ex. liver). Sensitivity: 2.4 µM (0.3 µg/ml). Assay-time: < 2 hours. Collagen is a main component of extracellular matrix. Dysregulation in collagen production results in pathologies such as fibrosis (too much collagen), or osteoarthritis (too little collagen). Thus measurement of collagen production is important in many disease related studies.
Abcam MnTBAP chloride, Supero x ide dismutase (SOD) mimetic, 50MG
MW 879.1 Da. Cell-permeable SOD mimetic. Potent peroxynitrite scavenger. Does not scavenge NO. Shows anti-inflammatory effects and reduces oxidative injury in vivo. Reduces ROS and shows a neuroprotective effect in spinal cord injury.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter Mouse CNR1 (CB1) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse CNR1 (CB1) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure CNR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Mouse CXCL16 (CXCR6) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse CXCL16 (CXCR6) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mCXCR6 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress GPR88 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0357E2ACP1L)
The PathHunter GPR88 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR88 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR88 and EA-tagged β-Arrestin-2. Activation of GPR88 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress FPR1 Total Internalization Assay, 10pl Kit. (93-0873E3CP0L)
The PathHunter FPR1 Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of FPR1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged FPR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the FPR1 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress UTR2 Total GPCR Internalization Assay, 2-Plate Kit. (93-0746E3CP5M)
The PathHunter UTR2 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of UTR2 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged UTR2 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the UTR2 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress ADRB1 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0113E2CP2L)
The cAMP Hunter ADRB1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. isoproterenol) based activation of ADRB1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADRB1, a naturally Gs coupled GPCR. Upon activation of ADRB1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress mCXCR7 U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0689E3MCP5M)
The PathHunter mCXCR7 (CMKOR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL12/SDF-1α) based activation of mCXCR7 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCXCR7 and EA-tagged β-Arrestin-2. Activation of mCXCR7 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.