General Cell Based Assays
Eurofins Discoverx cAMP Hunter eXpress GRM4 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0117E2CP24L)
The cAMP Hunter GRM4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. L-glutamate) based activation of GRM4 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM4, a naturally Gi/Go coupled GPCR. Upon activation of GRM4, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress c-Ret-GFRα2 Functional Assay, 10pl Kit. (93-0816E3CP16L)
The PathHunter eXpress c-Ret-GFRα2 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα2 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα2 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the cynomolgus version of the protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human & Mouse Total β-Arrestin 2 Detection Kit, Control Lysate
HTRF Human & Mouse Total β-Arrestin 2 Detection Kit, Control Lysate
Eurofins Discoverx cAMP Hunter eXpress PTGDR CHO-K1 GPCR Assay, 2-Plate Kit. (95-0110E2CP2M)
The cAMP Hunter PTGDR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin D2) based activation of PTGDR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGDR, a naturally Gs coupled GPCR. Upon activation of PTGDR, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress VIPR1 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0093E2CP2M)
The cAMP Hunter VIPR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. VIP) based activation of VIPR1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type VIPR1, a naturally Gs coupled GPCR. Upon activation of VIPR1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter NPY2R Bioassay Kit, 10-Plate. (95-0077Y2-00056)
The cAMP Hunter NPY2R Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. peptide YY) based activation of NPY2R GPCR activity via detection of levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type NPY2R, a naturally Gi coupled GPCR. Upon activation of NPY2R, the (decrease/increase) in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter FGFR4-β-Klotho Bioassay Kit, 10pl. (93-1060Y3-00090)
The PathHunter FGFR4-β-Klotho Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses FGF19-induced activation of FGFR4-β-Klotho RTK receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged FGFR4 and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, β-Klotho. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress GPR78 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0370E2ACP1L)
The PathHunter GPR78 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR78 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR78 and EA-tagged β-Arrestin-2. Activation of GPR78 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Bioss Plasma kallikrein light chain
Plasma kallikrein light chain Primary Antibody Unconjugated Host Species Rabbit Target Species Human Rat Clonality Monoclonal Applications WB IHC-P IHC-F IP IF RecombinantConcentration 1ug/ul Size 100 ul Storage Buffer 10mM phosphate buffered saline(pH 7 4) with 150mM sodium chloride 0 05% BSA 0 02% sodium azide and 50% glycerol
Eurofins Discoverx PathHunter eXpress MRGPRX2 CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0309E2CP0L)
The PathHunter MRGPRX2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. coristatin-14) based activation of MRGPRX2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MRGPRX2 and EA-tagged β-Arrestin-2. Activation of MRGPRX2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress SSTR4 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0308E2CP2M)
The PathHunter SSTR4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. somatostatin) based activation of SSTR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SSTR4 and EA-tagged β-Arrestin-2. Activation of SSTR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress FPR1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0314E2CP0M)
The PathHunter FPR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. formylpeptides) based activation of FPR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged FPR1 and EA-tagged β-Arrestin-2. Activation of FPR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress EBI2 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0437E2ACP21M)
The PathHunter EBI2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. hydroxycholesterols) based activation of EBI2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged EBI2 and EA-tagged β-Arrestin-2. Activation of EBI2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
TRIBIOSCIENCE INC Nicotinamide N-methyltransferase (NNMT) Inhibitor Screening Assay Kit, 100 Tests
NNMT inhibitor screening kit provides the easiest, most accurate, and simplest approach for high-throughput screening of NNMT inhibitors. The free thiol group of the homocysteine can be detected with a thiol probe generating an enhanced fluorescent signal at Ex/Em = 400/465 nm.
Eurofins Discoverx AssayComplete Cell Culture Kit-114, (92-3114G)
AssayComplete Cell Culture Kit-114 is an optimized media kit intended for use in culturing and propagating Eurofins DiscoverX cell lines. This kit contains the base medium, relevant serum, and pen/strep required to produce a full cell culture medium for optimal cell culture results. This product is provided as a 3-component kit which will produce approximately 550 mL of finished media. Please refer to cell line specific datasheet to determine the recommended cell culture kit. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.