General Cell Based Assays
Eurofins Discoverx PathHunter eXpress F2RL3 (PAR4) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0279E2CP0L)
The PathHunter F2RL3 (PAR4) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serine proteases) based activation of F2RL3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged F2RL3 and EA-tagged β-Arrestin-2. Activation of F2RL3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Arbor Assays Ceruloplasmin Colorimetric Activity Kit (2 Plate)
The DetectX Ceruloplasmin Activity Kit quantitatively measures ceruloplasmin activity in serum and urine samples.
Eurofins Discoverx PathHunter MCHR1 Bioassay Kit, 10-Plate. (93-0940Y3-00150)
The PathHunter MCHR1 Bioassay kit provides a robust, highly sensitive, and easy-to-use functional cell-based assay to measure drug potency and detect neutralizing antibodies. The bioassay kit contains all the materials needed for a complete assay, including cryopreserved cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The ready-to-use cryopreserved cells have been manufactured to ensure assay reproducibility and faster implementation from characterization to lot release. This bioassay has been optimized for a 96-well plate format. The protocol can be optimized further for running the assay in a high-throughput 384-well plate format. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx cAMP Hunter™ Human AVPR2 Gs Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human AVPR2 Gs Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure AVPR2 (GPCR) activity via increased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress GPR157 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0414E2ACP2M)
The PathHunter GPR157 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR157 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR157 and EA-tagged β-Arrestin-2. Activation of GPR157 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical Estradiol 3-(β-D-Glucuronide) (sodium salt), Purity: ≥95%, CAS: 14982-12-8, 5 mg
A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM)
Eurofins Discoverx PathHunter eXpress ACVRL1/BMPR2 Dimerization Assay, 10pl Kit. (93-0962E3CP22L)
The PathHunter ACVRL1/BMPR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/BMPR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVRL1 target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/BMPR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress C5AR1 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0079E2CP2M)
The cAMP Hunter C5AR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. C5a) based activation of C5AR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type C5AR1, a naturally Gi/Go coupled GPCR. Upon activation of C5AR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery R-PLEX Rat MIP-3 ASY
The R-PLEX Rat MIP-3alpha Assay Kit from Meso Scale Discovery is a multiplex immunoassay for measuring rat MIP-3alpha in various biological fluids It uses MSD s electrochemiluminescent detection for high sensitivity and a wide dynamic range with low sample volume An MSD instrument like QuickPlex is needed to read the plate The kit includes a 96-well plate with capture and detection antibodies plus calibrators and controls Detection limits are 1 52 pg/mL to 1500 pg/mL for rat MIP-3alpha
AMERICAN RESEARCH PRODUCTS INC ENDO-BETA-MANNANASE ASSAY KIT
503029786 ENDO-BETA-MANNANASE ASSAY KIT
AMERICAN RESEARCH PRODUCTS INC 3-A HYDROXYSTEROID DEHYDRO KIT
503029864 3-A HYDROXYSTEROID DEHYDRO KIT
AMERICAN RESEARCH PRODUCTS INC GLUTATHIONE S-TRANSFERASE KIT
503029842 GLUTATHIONE S-TRANSFERASE KIT