General Cell Based Assays
Eurofins Discoverx AssayComplete Cell Plating 38 Reagent, 500. (93-0563R38B)
AssayComplete Cell Plating 38 Reagent is an optimized cell plating reagent for use in plating of Eurofins DiscoverX cell lines for assays. This reagent was optimized for maximal cell health and ligand responsiveness during assays while eliminating hormones and growth components which may lead to increased basal activity. This product is provided as a bottle of 500 mL. Please refer to cell line specific datasheet to determine the recommended cell plating reagent. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.
Eurofins Discoverx PathHunter eXpress PROKR1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0303E2CP0M)
The PathHunter PROKR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PROKR1 and EA-tagged β-Arrestin-2. Activation of PROKR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCR2 Total GPCR Internalization Assay, 10pl Kit. (93-0679E3CP5L)
The PathHunter CCR2 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CCR2 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged CCR2 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CCR2 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Medchemexpress LLC cGAS Human His 5ug
cGAS is a cytosolic DNA sensor cGAS binds double-stranded DNA (dsDNA) and catalyzes the generation of cyclic guanosine-adenylate (cGAMP) which in turn activates the STING protein cGAS induces the production of type I interferon (IFN-I) and pro-inflammatory cytokines cGAS Protein Human (His) is a recombinant cGAS protein expressed in E coli with a C-6 His tag
Eurofins Discoverx cAMP Hunter eXpress CCR7 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0070E2CP2L)
The cAMP Hunter CCR7 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL19) based activation of CCR7 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CCR7, a naturally Gi/Go coupled GPCR. Upon activation of CCR7, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress OPRM1 Total GPCR Internalization Assay, 10pl Kit. (93-0745E3CP5L)
The PathHunter OPRM1 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of OPRM1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged OPRM1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the OPRM1 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress HTR1A CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0696E2CP0M)
The PathHunter HTR1A eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serotonin) based activation of HTR1A GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR1A and EA-tagged β-Arrestin-2. Activation of HTR1A stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Ammonia Assay Kit
Ammonia Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter eXpress CX3CR1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0956E2CP0M)
The PathHunter CX3CR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CX3CL1/fractalkine) based activation of CX3CR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CX3CR1 and EA-tagged β-Arrestin-2. Activation of CX3CR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter MC4R Bioassay Kit, 2-Plate. (93-0211Y3-00085)
The PathHunter MC4R Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. αMSH) based activation of MC4R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MC4R and EA-tagged β-Arrestin-2. Activation of MC4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress mPTAFR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0614E2MCP2M)
The PathHunter mPTAFR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PAF) based activation of mPTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mPTAFR and EA-tagged β-Arrestin-2. Activation of mPTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GPR25 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0368E2ACP2L)
The PathHunter GPR25 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR25 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR25 and EA-tagged β-Arrestin-2. Activation of GPR25 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress F2RL3 (PAR4) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0279E2CP0L)
The PathHunter F2RL3 (PAR4) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serine proteases) based activation of F2RL3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged F2RL3 and EA-tagged β-Arrestin-2. Activation of F2RL3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Arbor Assays Ceruloplasmin Colorimetric Activity Kit (2 Plate)
The DetectX Ceruloplasmin Activity Kit quantitatively measures ceruloplasmin activity in serum and urine samples.
Meso Scale Discovery U-PLEX Mouse IP-10 ASY
The Meso Scale Discovery U-PLEX Mouse IP-10 Assay is a multiplex immunoassay kit that enables simultaneous quantitative measurement of mouse interferon gamma-induced protein 10 (IP-10) in serum plasma and cell culture supernatants It utilizes electrochemiluminescent detection technology on patterned arrays for high sensitivity and broad dynamic range The assay requires 50 L or less sample volume and can be read on the MESO QuickPlex SQ 120 instrument The kit includes a 96-well plate coated with capture antibodies detection antibodies calibrators and controls needed to perform the assay