Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ InSolution™ MG-132 in EtOH, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
MilliporeSigma™ Calbiochem™ MG-132, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).
MilliporeSigma™ Calbiochem™ MK-2 Inhibitor IV, MK-25
The MK-2 Inhibitor IV, MK-25 controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Oridonin, R. rubescens
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.
MilliporeSigma™ Calbiochem™ Nifedipine
Relatively selective blocker of L-type Ca2+ channels.
MilliporeSigma™ Calbiochem™ Ouabain, Octahydrate
Inhibits Na+,K+-ATPase.
MilliporeSigma™ Calbiochem™ InSolution™ Nocodazole
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.
MilliporeSigma™ Calbiochem™ LY 83583
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 μM).
MilliporeSigma™ Calbiochem™ InSolution™ PERK Inhibitor I, GSK2606414
A cell-permeable pyrrolopyrimidinamine compound that acts as a highly potent inhibitor against EIF2AK3/PERK-catalyzed EIF2α Ser51 phosphorylation in kinase assays (IC50 = 0
MilliporeSigma™ Calbiochem™ InSolution™ AEBSF, Hydrochloride
A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride in H2O.
MilliporeSigma™ Calbiochem™ ApoE4 Modulator, PH002
A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby reversing the detrimental effects of ApoE4.
MilliporeSigma™ Calbiochem™ InSolution™ BAY 11-7082
Target: TNF-a-inducible phosphorylation of IkBa
MilliporeSigma™ Calbiochem™ BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).
MilliporeSigma™ Calbiochem™ BAY 11-7082
The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ Substance P
Neuropeptide found in high concentrations in the gut.