Protein Purification Reagents and Kits
AdipoGen FGF-23 msFc hrec
Recombinant protein. Mouse FGF-23 aa25-251 is fused at the C-terminus to the Fc portion of human IgG1. Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Source/Host HEK 293 cells. Purity >90% SDS-PAGE. Lyophilized. Contains PBS. FGF-23 Fibroblast growth factor 23 is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets ADHR and of hyperphosphatemic familial tumoral calcinosis HFTC.
AdipoGen FTO human rec His
Protein. Human FTO aa 2-505 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content <1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Purity >90% SDS-PAGE. FTO Fat mass-and obesity-associated gene is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
AdipoGen Asprosin human rec His
Recombinant protein. Human asprosin aa 2732-2871 is fused at the C-terminus to a His-tag. Source E. coli. Lyophilized from 0.2µm-filtered solution in 50mM Tris-HClpH 8.2, 200mM NaCl. Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein pro-Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein Kinase A. Reduction of Asprosin levels protects against metabolic syndrome-associated hyperinsulinism. Asprosin may act as a circulating hunger signal. Indeed, peripherally injected recombinant asprosin can cross the blood-brain barrier and intracerebroventricular i.c.v. injection of recombinant asprosin stimulated appetite in wild-type mice, indicating a central mechanism of action.
Sigma Aldrich Fine Chemicals Biosciences p53 Protein 10 181g Ful
p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases including choroid plexus papilloma lung cancer head/neck squamous cell carcinomas oesophageal squamous cell carcinoma Li-Fraumeni syndrome and hereditary adrenocortical carcinoma.
Bioworld CDI-ACTIVATED SEPAROPOREA
CDI-ACTIVATED SEPAROPORE (AGAROSE) 4B-CL: CDI-activated Separopore 4B Pre-activated medium for immobilization of ligands containing primary amines.; N,N\'-Carbonyl diimidazole (CDI) mediated activation of Separopore matrix to allow cou...
Hampton Research HR2-943-01/StockOptions MES #01 pH 5.2, 185 ml
HR2-943-01/StockOptions MES #01 pH 5.2, 185 ml. Please note items from this supplier are non-returnable.
Cell Signaling Technology SimpleChIP Human CDKN1A Promoter Primers 500 µl
SimpleChIP Human CDKN1A Promoter Primers 500 µl
Biolegend MojoSortTM Human Pan Monocyte
MojoSort™ Human Pan Monocyte Isolation Kit; Reactivity: Human; Apps: Cell Sep - Neg; Size: 20 tests
New England Biolabs, Inc. NEBNext LV Unique Dual Index Primers Set 5 - 96 reactions
NEBNext LV Unique Dual Index Primers Set 5 - 96 reactions
Revvity Health Sciences Inc Phospho-AKT (Thr308) Terbium Surefire Ultra Detection Kit, 500 Assay Points
Phospho-AKT (Thr308) Terbium Surefire Ultra Detection Kit, 500 Assay Points
Cell Signaling Technology Phospho-c-Myc Thr244 F3G5K Rabbit mAb 20 ul
Phospho-c-Myc Thr244 F3G5K Rabbit mAb 20 ul