The patent-pending S-Trap™ brings universal, simple and inexpensive sample preparation to bottom-up proteomics. One easy-to-use spin column combines sample concentration, clean up and digestion. S-Trap™ sample processing does not require any specialized equipment nor training. From µg to mg scales, your samples are ready in about an hour. S-Traps™ eliminate one of the greatest sources of variability – inconsistent lysis and protein solubilization – by using strong 5% SDS for all samples. This almost universal protein solvent is removed in the protein trap of the S-Trap™, which retains all undigested proteins but does not retain small molecules including the SDS used to extract and handle proteins.