Cell Line Lysates
ABclonal Technology PTPN1 Rabbit pAb
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which catalyzes the hydrolysis of phosphate monoesters on tyrosine residues. PTPs are key signaling molecules that regulate cellular processes such as growth, differentiation, the cell cycle, and oncogenic transformation. This PTP acts as a negative regulator of insulin signaling by dephosphorylating the insulin receptor kinase. It also dephosphorylates epidermal growth factor receptor kinase, JAK2, and TYK2 kinases, implicating it in cell growth control and responses to interferon. Two transcript variants encoding different isoforms have been identified for this gene.
Cayman Chemical SaccharocarcIn B 2.5mg
A macrocyclic lactone antibiotic; active against Gram-positive bacteria and C. trachomatis
ABclonal Technology Integrin alpha-6/ITGA6
The gene encodes a member of the integrin alpha chain family of proteins Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family The alpha 6 beta 4 integrin may promote tumorigenesis while the alpha 6 beta 1 integrin may negatively regulate erbB2 HER2 signaling Alternative splicing results in multiple transcript variants
Cayman Chemical RubIgInon D2 2.5mg
A polyketide; active against S. aureus and E. coli in agar diffusion assays at 64 UG/disc; inhibits growth of HM02, KATO III, HepG2, and MCF-7 cancer cells (GI50s = 0.1, 0.7, <0.1, and 7.5 µmol/L)
ABclonal Technology CREB3L2 Rabbit pAb
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene.
Abcam Human PLK2 knockout HCT116 cell lysate.
Human PLK2 knockout HCT116 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HOXA9 knockout HEK-293 cell lysate.
Human HOXA9 knockout HEK-293 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human BRAP knockout HEK-293T cell lysate.
Human BRAP knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx InCELL Hunter™ Human MEK1 Kinase Target Engagement Cell-Based Assay Kit (A549)
The InCELL Hunter™ Human MEK1 Stable Cell Line Target Engagement Assay (A549) contains a stable clonal cell line used to measure target engagement via compound-induced stabilization of MEK1 target protein. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
ABclonal Technology Bcl10 Rabbit pAb
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Abcam Human SSR4 knockout HEK-293T cell lysate.
Human SSR4 knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human BRWD1 (WDR9) knockout HeLa cell lysate.
Human BRWD1 (WDR9) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Tn 420E 2.5mg
A bacterial metabolite; scavenges DPPH radicals in vitro (IC50 = 1.3 μM); reduces TBARS in rat liver microsomes by 72% at 100 μg/ml; is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml); is cytotoxic to P388 and KB cancer cells (EC50s = 0.022 and 0.3 μg/ml, respectively)