Immunosuppressant Drug Testing Controls and Calibrators
AdipoGen Everolimus
Chemical. CAS 159351-69-6. Formula C53H83NO14. MW 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available Rapamycin derivative that shows improved pharmacokinetics and pharmacodynamics. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 FKBP-12 to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin mTOR. More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to Rapamycin. Since mTORC2 is believed to play an important role in glucose metabolism and the immune system, selective inhibition of mTORC1 achieves many of the benefits of rapamycin without the associated glucose intolerance and immunosuppression Anticancer agent.
AdipoGen Everolimus
Chemical. CAS 159351-69-6. Formula C53H83NO14. MW 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available Rapamycin derivative that shows improved pharmacokinetics and pharmacodynamics. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 FKBP-12 to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin mTOR. More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to Rapamycin. Since mTORC2 is believed to play an important role in glucose metabolism and the immune system, selective inhibition of mTORC1 achieves many of the benefits of rapamycin without the associated glucose intolerance and immunosuppression Anticancer agent.
Diapharma Group, Inc. Technothrombin Thrombin Generation Assay (TGA) Control – Low, 5 x 1 mL
Technothrombin TGA (Thrombin Generation Assay) Control Low. Human plasma with decreased thrombin generation, lyophilized.
Med Vet International Amikacin Sulfate Injection (amikin) 500mg 2mL 10/box
Amikacin Sulfate Injection (amikin) 500mg 2mL 10/box
Abcam Everolimus, mTOR inhibitor, 25MG
MW 958.2 Da, Purity >98%. Potent mTOR inhibitor (IC₅₀ = 1.6 - 2.4 nM). Immunosupressant and anticancer activity in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Everolimus, mTOR inhibitor, 5MG
MW 958.2 Da, Purity >98%. Potent mTOR inhibitor (IC₅₀ = 1.6 - 2.4 nM). Immunosupressant and anticancer activity in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Mycophenolc ACD mthyl Ste 50mg
An H /K -ATPase inhibitor (Ki 46 nM) inhibits histamine- or dibutyryrl-cAMP-induced acid production in isolated rabbit gastric glands (IC50s 0.28 and 0.26 UM respectively)
AdipoGen Amikacin disulfate salt
Chemical. CAS 39831-55-5. Formula C22H43N5O13 . 2H2SO4. MW 781.76. Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.
Cayman Chemical Mycophenolc ACD mthyl Ste 25mg
An H /K -ATPase inhibitor (Ki 46 nM) inhibits histamine- or dibutyryrl-cAMP-induced acid production in isolated rabbit gastric glands (IC50s 0.28 and 0.26 UM respectively)
Med Vet International Amikacin Sulfate 250mg/ml 2ml 10/box Generic of Amikin
Amikacin Sulfate 250mg/ml 2ml 10/box Generic of Amikin
Cayman Chemical MycophenolIc AcId DGlucuro 5mg
A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases
Cayman Chemical MycophenolIc AcId 100mg
Source Recombinant human ubiquitin expressed in E coli Amino acids 1-76 MW 8 5 kDa