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Glutamate one of the two acidic proteinogenic amino acids is also a key molecule in cellular metabolism. The synthesis of KG from glutamate by glutamate dehydrogenase is a key TCA cycle anaplerotic reaction. In humans glutamate plays an important role both in amino acid degradation and disposal of excess or waste nitrogen. Within the mammalian nervous system glutamate is the most abundant excitatory neurotransmitter. It is believed to be involved in learning and memory and may also be involved in diseases like amyotrophic lateral sclerosis autism some forms of mental retardation and Alzheimer disease. Glutamate is present in a wide variety of foods and has been used as a flavor enhancer in food industry.
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2356 Glucose Standard 500 mg/dL (5 g/L). 500mg/dL glucose standard solution for use with YSI 2300, 2700, 2900 Series and 7100 analyzers (125mL). Minimum order quantity 2.
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MW 960.8 Da, Purity >95%. Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC₅₀ values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.
A stable, cell-permeable molecule which generates free glutamic acid upon hydrolysis of the ester bond by cytoplasmic esterases; used in experiments to increase levels of cytoplasmic glutamic acid; also used to synthesize 5-octyl ester derivatives, including 5-octyl α-ketoglutarate, for delivery to cells
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