Substrates
Enzo Life Sciences Ac-LEHD-AFC (10mg). CAS: 210345-03-2
Fluorogenic substrate for caspase-9. Alternative name: Caspase 9 substrate (fluorogenic). Formula: C33H38F3N7O11. MW: 765.7. Purity: ≥96% (HPLC). Formulation: Lyophilized. Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Src substrate 2 (1mg)
This peptide, YIYGSFK, was derived through a random combinatorial peptide library method and is a specific and efficient substrate for the scr family of kinases. The Km of YIYGSFK for p60c-src is 55µM. Purity: ≥95% (HPLC). Formulation: Lyophilized. Solubility: Soluble in water. Long Term Storage: -20°C.
Revvity Health Sciences Inc LANCE Ultra Phospho-PLK (Ser137) Ulight Peptide Substrate, 0.5 nmole
LANCE Ultra Phospho-PLK (Ser137) Ulight Peptide Substrate, 0.5 nmole
Research Products International Corp X-Phos, BCIP, 5 G
Colorimetric substrate for Alkaline phosphatase activity in blotting immunohistochemical and cytochemistry techniques. Forms a purple insoluble precipitate when used in conjunction with NBT.
Medchemexpress LLC Z-Leu-Leu-Leu-AMC | 152015-61-7 | 98.4% | 1 MG
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate utilized for measuring the chymotrypsin-like protease activity of the 20S proteasome.
- Purity of 98.4%
- Solid appearance, white to off-white in color
- For measuring chymotrypsin-like protease activity of the 20S proteasome
- Powder storage: -80°C for 2 years or -20°C for 1 year
- Solvent storage: -80°C for 6 months or -20°C for 1 month
Abcam Carbo x yl-DCFDA (5(6)-Carbo x y-2',7'-dichlorofluorescein diacetate), Fluorogenic esterase substrate, 100MG
MW 529.28 Da, Purity >85%. Amine-reactive, fluorogenic, non-selective esterase substrate. Hydrolyses to DFCA (ab145439) fluorophore intracellularly. Labels intact cells. 2,7-Dichlorofluorescein (ab146332) derivative and DCFDA N-succinimidyl ester (ab145286) precursor.
The product is subject to the following: Abcam Restricted Use Statement
eMolecules 115144-35-9 | D-Luciferin potassium salt | Apollo Scientific | MFCD00044928 | 318.410 | C11H7KN2O3S2 | 0.000 | [K+].Oc1ccc2nc(sc2c1)C1=N[C@H](CS1)C([O-])=O | 100mg | 562533490
D-Luciferin potassium salt | Apollo Scientific | 115144-35-9 | MFCD00044928 | 318.410 | C11H7KN2O3S2 | 0.000 | [K+].Oc1ccc2nc(sc2c1)C1=N[C@H](CS1)C([O-])=O | 100mg | 562533490
Enzo Life Sciences Ac-IETD-AFC (10 mg)
Caspase and granzyme substrate. Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site. Alternative Name: Caspase 8 substrate (fluorogenic), Granzyme B substrate (fluorogenic). Formula: C31H38F3N5O12. MW: 729.7. Purity: ≥98% (HPLC). Sequence Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin). Appearance: White to off-white powder. Solubility: Soluble in DMSO. Long Term Storage: -20°C. Handling: Keep cool and dry.
Apexbio Technology LLC Ac-IETD-AFC,5mg CAS# 211990-57-7
Ac-IETD-AFC is a fluorogenic substrate of caspase-8 and possesses amino aicd sequence IETD which is recognized by caspase-8-mediated proteolysis. It is also a substrate for caspase-3 processing enzyme, caspase-10, and granzyme B. Caspase activity can be quantified by fluorescent detection of free AFC at Ex. = 400 nm and Em. = 505 nm. Ac-IETD-AFC can be used to identify and quantify caspase-8 activity in apoptotic cell lysates and to study events downstream of caspase-8 activation. Other sizes are also available. Please inqury us for quote.
Abcam L-alpha-Phosphatidylinositol, Phospholipase C substrate, 1G
MW 867.14 g/mol. Phospholipase C substrate. Phospholipid membrane component. Inositol phosphate precursor. Stimulates vascular Ca²+-dependent protease autolysis.
The product is subject to the following: Abcam Restricted Use Statement
Sino Biological Peptide Substrates: Modified AKT Substrate
The Modified AKT Substrate peptide sequence (modified-CKRPRAASFAE) is based on the N-terminus of GSK3.
Biotium Coelenterazine FCP
Coelenterazine fcp is a synthetic derivative of coelenterazine. The luminescence intensity of its aequorin complex is 135 times higher than that of aequorin formed from native coelenterazine. Coelenterazines are luminescent enzyme substrates for apoaequorin and Renilla luciferase. Apoaequorin is used as a calcium indicator. It binds coelenterazine to form an aequorin complex that emits light upon calcium binding and measures concentrations ~0.1 uM to >100 uM. Renilla luciferase is widely used as a reporter of transcription regulation and as a donor in bioluminescence resonance energy transfer (BRET) to study protein-protein interactions. Coelenterazines are also used for chemiluminescent detection of superoxide anions and peroxynitrite in cells or tissues. Coelentrazine analogs and water-soluble Aquaphile™ Coelenterazines are also available.Properties : Yellow solid soluble in MeOH or EtOH; Store at -20°C, protect from light; C25H24FN3O2; MW: 417.48.
Abcam Ceefourin™ 1, MRP4 inhibitor, 1MG
MW 294.4 Da, Purity >99%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 1.5 µM). Blocked transport of MRP4 substrates 6-Mercaptopurine, SN 38, cAMP, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 2 (ab145145).
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Boc-Glu-Lys-Lys-AMC | 73554-85-5 | 99.9% | 660.76 | 10 MG
Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin. It is intended for research use only.
- Sensitive fluorogenic substrate
- For urokinase-activated plasmin
- Research use only
Biotium HER-2 / CD340(HRB2/718), CF740 conjugate, 0.1mg/mL
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.