Isotopically Labeled Compounds
Medchemexpress LLC Desipramine-d4 | 61361-34-0 | 98.9% | 500 UG
Desipramine-d4 is the deuterium labeled Desipramine. It is for research use only and not sold to patients. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potential to influence the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Metolazone-d7 | 2714484-71-4 | 99.9% | 500 UG
Metolazone-d7 is deuterium labeled Metolazone, primarily used to treat congestive heart failure and high blood pressure. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cephalexin-d5 | 2101505-56-8 | 99.0% | 1 MG
Cephalexin-d5 is deuterium labeled Cephalexin, a potent, orally active, first-generation cephalosporin antibiotic. It works by disrupting the growth of bacterial cell walls, effectively killing gram-positive and some gram-negative bacteria. Cephalexin monohydrate is used in research for conditions like pneumonia, strep throat, and bacterial endocarditis. This product is for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Trimethoprim-d9 | 1189460-62-5 | 99.6% | 5 MG
Trimethoprim-d9 | 1189460-62-5 | 99.6% | 5 MG
Medchemexpress LLC Acetylcholine-d4 bromide | 93449-31-1 | 98.69% | 5 MG
Acetylcholine-d4 (bromide) is the deuterium labeled Acetylcholine bromide. This compound is used as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development, and deuteration may affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Intended for research use only
- Not for sale to patients
Medchemexpress LLC Lidocaine-d10 | 851528-09-1 | 98.9% | 5 MG
Lidocaine-d10 | 851528-09-1 | 98.9% | 5 MG
Medchemexpress LLC Norethindrone-d6 | 2376036-05-2 | 99.9% | 5 MG
Norethindrone-d6 is the deuterium-labeled version of Norethindrone, a female progestin approved by the FDA for treating endometriosis, uterine bleeding due to abnormal hormone levels, and secondary amenorrhea. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Azide groups.
- Can be used as a tracer and as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes like deuterium into drug molecules is primarily for quantitation as tracers during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
- Its Alkyne group enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
Medchemexpress LLC Cyclosporin A-d4 | 59865-13-3 | 99.6% | 1 MG
Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant that binds to cyclophilin and inhibits the phosphatase activity of calcineurin with an IC50 of 5 nM. It also inhibits CD11a/CD18 ad.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules, primarily as tracers for quantitation during the drug development process.
- Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Trospium-d8 chloride | 10405-02-4 | 1 MG
Trospium-d8 (chloride) is the deuterium-labeled form of Trospium chloride. Trospium chloride is an orally active, specific, and competitive antagonist of muscarinic cholinergic receptors (mAChRs), exhibiting antimuscarinic activity. It binds with high affinity to muscarinic receptors M1, M2, and M3, but not nicotinic cholinergic receptors.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporation of stable heavy isotopes can affect pharmacokinetic and metabolic profiles of drugs
Cayman Chemical MIltefosIn-d4 1mg
An internal standard for the quantification of miltefosine by GC- or LC-MS
Cayman Chemical SulfamethazIn-d4 10mg
An internal standard for the quantification of sulfamethazine by GC- or LC-MS
Medchemexpress LLC Alfuzosin-d3 | 1006724-55-5 | 99.9% | 1 MG
Alfuzosin-d3 is deuterium labeled Alfuzosin. This compound can be used as a tracer and as an internal standard for quantitative analysis. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Dxd-d5 (Exatecan-d5 derivative for ADC) | 1599440-33-1 | 98.9% | 498.51 | 1 ML
Dxd-d5 is a deuterium labeled Dxd, which is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC (DS-8201a).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
- Intended for research use only.
Medchemexpress LLC Carbamazepine-d8 | 1538624-35-9 | 1 MG
Carbamazepine-d8 is the deuterium labeled Carbamazepine. It is a sodium channel blocker and an anticonvulsant agent, with an IC50 of 131 μM. This compound is for research use only and not sold to patients.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Dimetridazole-d3 (1,2-dimethyl-5-nitroimidazole-d3) | 64678-69-9 | 99.8% | 5 MG
Dimetridazole-d3 is a deuterium labeled nitroimidazole antibiotic that inhibits protein synthesis in cultures of Campylobacter jejuni and is genotoxic. It is used in the research of protozoal and bacterial infections, and can serve as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled
- Nitroimidazole antibiotic
- Inhibits protein synthesis in cultures of Campylobacter jejuni
- Genotoxic
- Suitable for research of protozoal and bacterial infections
- Functions as a tracer
- Functions as an internal standard for quantitative analysis
- Molecular weight: 144.15
- Formula: C5H4D3N3O2
- Appearance: solid
- Color: white to off-white
- Solubility in DMSO: 50 mg/mL