Isotopically Labeled Compounds
Medchemexpress LLC Ketorolac-d5 | 1215767-66-0 | 98.8% | 5 MG
Ketorolac-d5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Store powder at -20°C for 3 years; 4°C for 2 years.
- Store in solvent and stock solution at -80°C for 6 months; -20°C for 1 month.
Medchemexpress LLC Metaxalone-d3 | 1192812-66-0 | 98.0% | 1 MG
Metaxalone-d3 is a deuterium labeled Metaxalone, an FDA-approved muscle relaxant. It primarily acts on the central nervous system to achieve muscle relaxation by inhibiting polysynaptic reflex arcs. This compound also inhibits MAO-A, demonstrating anti-inflammatory and antioxidant effects. It inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia.
- Deuterium labeled compound
- FDA-approved muscle relaxant
- Inhibits polysynaptic reflex arcs
- Inhibits MAO-A
- Provides anti-inflammatory and antioxidant effects
- Modulates NF-κB and related signaling pathways
- Decreases MAO-A expression and activity in IL-1β-treated microglia
- Used as a tracer for quantitation in drug development
Medchemexpress LLC Hordenine-d6 | 1346598-66-0 | 98.03% | 171.27 | 1 MG
Hordenine-d6 is a deuterium-labeled variant of Hordenine, an alkaloid naturally occurring in plants. The unlabeled form of Hordenine has been shown to inhibit melanogenesis by suppressing the production of cyclic adenosine monophosphate (cAMP). Deuterium-labeled compounds incorporate stable heavy isotopes of elements like hydrogen and carbon into drug molecules. This labeling technique is primarily used as a tracer for quantitative analysis during drug development, and it has garnered attention for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer in research applications.
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes can affect the pharmacokinetic and metabolic profiles of compounds.
- It is a deuterium labeled compound.
Medchemexpress LLC Hordenine-d6 | 1346598-66-0 | 171.27 | C10H9D6NO | 10 MG
Hordenine-d6 is the deuterium-labeled analog of hordenine provided for use as an isotope-labeled standard or tracer in analytical, metabolic, and pharmacokinetic studies. It is intended for research applications where deuterated standards improve quantitation and metabolic tracking.
- Deuterium-labeled hordenine for isotope tracing.
- Molecular formula C10H9D6NO and molecular weight 171.27.
- CAS number 1346598-66-0.
- Recommended solubility: DMF, DMSO, ethanol at reported concentrations.
- Storage: 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
- Supplied as a small research pack suitable for analytical workflows.
Medchemexpress LLC 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy-2,4,6-d3)methyl]- | 1192812-66-0 | 98.0% | 5 MG
Metaxalone-d3 is a deuterium-labeled derivative of Metaxalone, an FDA-approved muscle relaxant. It primarily acts on the central nervous system by inhibiting polysynaptic reflex arcs. It also inhibits MAO-A, offering anti-inflammatory and antioxidant effects. Stable heavy isotopes have been incorporated into drug molecules for tracing and can influence drug pharmacokinetics and metabolic profiles.
- Deuterium labeled Metaxalone
- FDA-approved muscle relaxant
- Inhibits polysynaptic reflex arcs
- Inhibits MAO-A, providing anti-inflammatory and antioxidant effects
- Isotopic enrichment of 99.10%
Cayman Chemical RaloxIfen-d4hydrochlorIde 5mg
A natural alkaloid that inhibits LPS and CpG DNA (Kds 1 24 and 0 66 UM) which are two PAMPs involved in triggering sepsis