RNAi Screening Libraries
Cayman Chemical Humn LIvR Receptr Homolog 96
Inhibitor of Cdk1/cyclin B and Cdk/p25 (IC50s 600 and 400 nM respectively)
Cayman Chemical Humn LIvR Receptr Homolog 384
A multiple kinase inhibitor blocking Met Tie2 VEGF2 TrkA TrkB and TrkC with IC50 values of 2 7 8 0 9 2 0 85 4 6 and 0 83 nM respectively orally bioavailable and penetrates the blood brain barrier suppressing the growth of subcutaneous and intracerebroventricular xenograft tumors in mice
Cayman Chemical sn-glycero-3-PhosphocholIn 25g
A fluorescent probe that crosses the blood-brain barrier binds with high affinity to AB plaques (Ki 10 nM) ex/em spectra 475/625 nm respectively far-red emission occurs upon binding to AB
Cayman Chemical Mouse LIvR X Receptr Alpha 96
A PEGylated form of cholesterol has been used in the synthesis of liposomes for targeted drug delivery
Cayman Chemical TrnsfRrIn Receptr ProteIn 50uL
A phenylethanoid glycoside selectively inhibits aldose reductase over maltase and sucrase (IC50s 0.071 300 and 277 UM respectively for the rat enzymes) scavenges superoxide radicals in a cell-free assay and inhibits AAPH-induced hemolysis in isolated rat red blood cells decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1 1 and 10 UM protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 4.8 Ug/ml) prevents decreases in bone strength in ovariectomized mice from 10-40 mg/kg
Cayman Chemical OrexIn 2 Receptr ReporTR1ea
A linker molecule has been used to conjUGate SN-38 to phlorizin or phloretin to increase the selectivity of SN-38 for cancer cells
Cayman Chemical MelnocortIn4 Receptr Rever 1ea
An MC4R antagonist selectively inhibits [Nle4D-Phe7]-a-MSH binding to recombinant human MC4R over MC1R and MC3R (IC50s 11.63 >10000 and 1115 nM respectively) inhibits a-MSH-induced cAMP production in COS-1 cells expressing human MC4R from 0.1-100 UM reduces stress-induced decreases in the time spent in the light area of the light/dark exploration test in mice reverses restraint stress-induced decreases in food intake in rats
Cayman Chemical 1 2 3TrInonadecnoyl Glycero 1g
An internal standard for the quantification of vigabatrin by GC- or LC-MS
Cayman Chemical MelatonIn Receptr TYP 1Ah 10ug
A selective estrogen receptor modulator binds to ERa and ERB (Kis 380 and 410 nM respectively) increases vaginal weight and vaginal epithelial height (ED50s 0.48 and 0.39 mg/kg per day respectively) in an ovariectomized rat model of menopause increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits 17b-estradiol-induced estrogen response element-mediated transactivation in a reporter assay using MCF-7 cells
Cayman Chemical MInralocortIcoId Receptr BI 96
An internal standard for the quantification of myclobutanil by GC- or LC-MS
Cayman Chemical ndrogen Receptr BIoasy 96Wel
An ITP derivative has been used in the determination of NDPK activity in a coupled enzyme assay
Cayman Chemical Tol-LIke Receptr 7 LIgnd I 1mg
An orally active selective inhibitor of Cdk4 (IC50 11 nM) and Cdk6 (IC50 16 nM) with antiproliferative activity against retinoblastoma-positive tumor cells blocking retinoblastoma phosphorylation and inducing G1 arrest used to demonstrate a role for insulin-activated cyclin D1-Cdk4 signaling in the control of glucose metabolism
Cayman Chemical Glucagon Receptr ntagonIst 5mg
A potent dual inhibitor of tyrosine and phosphoinositide kinases (IC50s 2-60 nM for p110a mTOR Src Abl and VEGFR) demonstrates 90 inhibition of tyrosine kinases and 50 50 nM) in vitro blocks VEGF-driven HUVEC tube formation (IC50 0 31 nM) inhibits MEKK2/MAP3K2 (IC50 31 nM)
Cayman Chemical sn-glycero-3-PhosphocholIn 5g
A semisynthetic with broad spectrum antibacterial properties used as part of antibiotic cocktails known as PANTA (with polymyxin B amphotericin B nalidixic acid and trimethoprim) and PANTAV (PANTA with vancomycin)
Cayman Chemical EP3 Receptr Blockng PeptID 1ea
An internal standard for the quantification of daunorubicin by GC- or LC-MS