Antibody-Binding Proteins and Conjugates
Biotium CD106 / VCAM1(1.4C3), CF488A conjugate, 0.1mg/mL
CD106 (also known as vascular cell adhesion molecule-1, or VCAM-1) is a member of the Ig superfamily of adhesion molecules. It is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. CD106 serves as a ligand for leukocyte beta-1 integrin VLA-4 and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biotium Thyroglobulin(6E1.), CF488A conjugate, 0.1mg/mL
Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a
Biotium Testosterone(4E1G2), CF488A conjugate, 0.1mg/mL
This MAb is highly specific to testosterone. Its affinity constant for testosterone is ~1010 M-1. In competitive binding immunoassay, it reacts with testosterone 100%, 11-beta-hydroxy testosterone 3.3%, 17-alpha-methyl testosterone <0.1%, 5-alpha DHT 0.8%, estradiol <0.1% and progesterone <0.1%. Testosterone, a steroid hormone from the androgen group, is derived from cholesterol. Testosterone is primarily secreted in the testes, but the ovaries and adrenal glands also produce smaller amounts. It is the principal male sex hormone and is responsible for the maturation of sex organs and the development of male secondary sex characteristics. The hormone is also involved in the growth of muscle mass and increases bone density and maturation. It functions by activating the androgen receptor and converting to estradiol and activation of estrogen receptors. Testosterone has been employed therapeutically to treat many conditions including infertility, lack of libido, osteopor
Biotium CD56 / NCAM(123C3.D5), CF594 conjugate, 0.1mg/mL
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135 kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are
Cayman Chemical FuregrelatesodIum salt 50mg
Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC50 value is 15 nM for human platelet microsomal thromboxane synthase.{1227,1228}
Biotium CD282 / TLR2(TLR2/221), CF647 conjugate, 0.1mg/mL
This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low
Abcam Cy5 Conjugation Kit (Fast) - Lightning-Link, 3 x 100UG
Cy5 conjugation / labeling in < 20 mins with 30 secs hands-on time using Cy5 Conjugation Kit (Fast) - Lightning-Link ab188288. 100% antibody recovery.
The product is subject to the following: Abcam Restricted Use Statement
Jackson Immuno Research Labs Cy3-IgG Fraction Monoclonal Mouse Anti-Fluorescein (FITC)
Cy3-IgG Fraction Monoclonal Mouse Anti-Fluorescein (FITC)
Jackson Immuno Research Labs Rhodamine (TRITC)-IgG Fraction Monoclonal Mouse Anti-Biotin
Rhodamine (TRITC)-IgG Fraction Monoclonal Mouse Anti-Biotin
Jackson Immuno Research Labs 18nm Colloidal Gold-AffiniPure Goat Anti-Horseradish Peroxidase (EM Grade)
18nm Colloidal Gold-AffiniPure Goat Anti-Horseradish Peroxidase (EM Grade)
Jackson Immuno Research Labs Rhodamine (TRITC)-IgG Fraction Monoclonal Mouse Anti-Fluorescein (FITC)
Rhodamine (TRITC)-IgG Fraction Monoclonal Mouse Anti-Fluorescein (FITC)
Jackson Immuno Research Labs Alexa Fluor 594-ChromPure Mouse IgG whole molecule
Alexa Fluor 594-ChromPure Mouse IgG whole molecule
Jackson Immuno Research Labs DyLight 405-ChromPure Mouse IgG whole molecule
DyLight 405-ChromPure Mouse IgG whole molecule
Jackson Immuno Research Labs Biotin-SP-ChromPure Mouse IgG Fab fragment
Biotin-SP-ChromPure Mouse IgG Fab fragment
Jackson Immuno Research Labs Biotin-SP-ChromPure Mouse IgG F(ab')2 fragment
Biotin-SP-ChromPure Mouse IgG F(ab')2 fragment