Antibody-Binding Proteins and Conjugates
Revvity Health Sciences Inc AlphaLISA Anti-Rabbit IgG-Fc Acceptor Beads, 5 mg
AlphaLISA Anti-Rabbit IgG-Fc Acceptor Beads, 5 mg
Cayman Chemical DnshensusodIum salt 50mg
An M2 and M4 muscarinic acetylcholine receptor antagonist (Kis 6 03 and 10 nM respectively) selective for M2 and M4 over M1 M3 and M5 receptors (Kis 30 9 66 07 and 537 03 nM respectively) increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo following local infusion at 1 UM and in the cortex at 5 mg/kg i p reverses deficits in novel object recognition and passive avoidance in aged rats as well as scopolamine-induced deficits in young rats
Cayman Chemical GncIclovIrsodIum salt 50mg
A plant metabolite and an aldose reductase 2 inhibitor (IC50 17 UM) inhibits glucose-induced sorbitol accumulation in lenses isolated from a transgenic mouse model overexpressing AKR1B1 reduces methylglyoxal-induced increases in COX-2 IL-6 IL-8 CCL2 and RAGE levels in ARPE-19 retinal epithelial cells
Cayman Chemical CefalothInsodIum salt 500mg
A nucleotide diphosphate for various biochemical research applications including studies of DNA synthesis substrate for nucleoside diphosphate kinases
Cayman Chemical LIfItegrastsodIum salt 50mg
A CYP1B1 inhibitor (IC50 0.01 UM) selective for CYP1B1 over CYP1A1 CYP1A2 CYP3A4 and CYP2D6 (IC50s 0.742 1.2 18 and 10 UM respectively) enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1
Cayman Chemical MaduramIcInamonIum salt 500mg
A tricyclic antidepressant binds to the norepinephrine and 5-HT transporters (Kd 1.41 and 19.6 nM respectively) binds to histamine H1 muscarinic acetylcholine and a1-adrenergic receptors (Kds 25 25 and 130 nM respectively) inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s 12 and 0.55 M respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 5.5 M) inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg i.v.
Cayman Chemical D-LucIferInpotasIum salt 500mg
An inhibitor of GVIA iPLA2 inhibits GVIA iPLA2 by 99.9 at 0.091 mol fraction in a mixed micelle activity assay is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8 inhibition respectively inhibits iPLA2B activity in cytosolic extracts from INS-1 cells overexpressing iPLA2B (IC50 ~50 nM) as well as iPLA2Y activity in mouse heart membrane fractions (IC50 ~1-3 M) inhibits glucose-induced increases in PGE2 production and insulin secretion in human pancreatic islets at 10 M inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2B in a concentration-dependent manner reduces blood glucose levels in an intraperitoneal glucose tolerance test and incidence of diabetes and increases serum insulin levels in NOD mice at 20 mg/kg 3 times per week
Cayman Chemical D-LucIferInpotasIum salt 50mg
Immunogen Synthetic peptide from the N-terminal region of human NF-KB (p65) Host Rabbit Species Reactivity ( ) Human chimpanzee monkey Applications WB MW 60 kDa
Cayman Chemical EsomeprazolesodIum salt 50mg
A fluorinated analog of AEA that serves as a substrate of FAAH (Km 29 UM) used to perform n-FABS against FAAH to identify novel inhibitors
Cayman Chemical 6-SIalylactosesodIum salt 50mg
A symmetric bis-glycolamide that inhibits the eIF2a phosphorylation-mediated unfolded protein response (IC50 5 nM in a cell-reporter assay) passes through the blood-brain barrier and significantly enhances learning and memory in mice and rats
Cayman Chemical LorglumIdesodIum salt 50mg
An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis 5.3 and 330 nM respectively) significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2
Cayman Chemical TazobactamsodIum salt 500mg
A melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values 10-27 and 158-513 nM respectively) used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways
Cayman Chemical PPAdodIum salt 50mg
An RXR agonist (EC50s 28 25 and 20 nM for RXRa RXRB and RXRY respectively in reporter assays) selective for RXRs over RARs (RARs EC50s 10 UM for RXRa RXRB and RXRY) induces apoptosis in MJ HuT 78 and HH CTCL cells at 10 UM inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models at 100 mg/kg per day reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 9.4 UM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 2.01 UM)