Actinonin is a naturally occurring antibacterial agent produced by Actinomyces. It inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, and is a potent reversible peptide deformylase (PDF) inhibitor (Ki: 0.28 nM). It also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α, acting as an apoptosis inducer with antiproliferative and antitumor activities.
- Naturally occurring antibacterial agent.
- Inhibits aminopeptidases (M, N, leucine).
- Potent reversible peptide deformylase (PDF) inhibitor.
- Inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α.
- Induces apoptosis.
- Exhibits antiproliferative and antitumor activities.
- Active against various gram-positive and gram-negative bacteria.
- Solid appearance, white to off-white color.
- Significant antitumor activity in prostate tumor xenograft model.