Next-Generation Sequencing Assays

Solutions for Genetic Analysis

Experience a World of Simplified NGS

Produce test results in as little as 24 hours with the Ion Torrent™ Genexus™ System. Next-generation sequencing (NGS) with Genexus requires very small sample input and quickly provides comprehensive genomic profiles for Oncomine™ Assays.

With the Genexus hands-off, automated testing workflow, your lab can go from specimen to report in a single day—producing comprehensive genomic profiles at unprecedented speed. Enjoy receiving NGS results within the same timeframe as immunohistochemistry (IHC) and other single-gene methods.

And because Genexus requires a low sample size—only 10 ng DNA/RNA or 20 ng of cfTNA—you can successfully sequence more samples in your lab. The set-up-and-go system makes NGS accessible even if your lab is new to the technology.

All Genetic Testing Research Solutions

Applied Biosystems SeqStudio Genetic Analyzer Ion GeneStudio S5 System Aneuploidy Detection Cystic Fibrosis Real-Time PCR Solution Pharmacogenomics Real-time PCR Solution Vaginal Microbiota Testing Real-Time PCR Detection

Lower Input for a Higher Success Rate

Get reliable NGS results for more samples with Oncomine Assays on the Genexus System. In oncology research, it is common that the tissue available for testing is small and often of inferior quality. With NGS platforms that require larger sample amounts, one out of four samples could be deemed unusable for sequencing.

Driven by Ion™ AmpliSeq™ HD technology, Oncomine Assays on the Genexus System require only 10 ng of nucleic acid input—and more than 95% of samples produce sequencing results.

Empower Your Lab for Maximum Results

Content for Pan-Cancer Analysis

Mutation, CNV, and fusion variant types across 50 key genes

Leading-Edge FusionSync Detection

Sensitive and specific—targeted isoform designs
Rare fusion detection

Molecular Tagging Capabilities

Enhanced low-level variant detection
Key for liquid biopsy testing

Test Tissue and Plasma Samples

One test, one workflow, multiple sample types
Maximizes the number of tumors that can be profiled

Systems and Technology

Simple, Intuitive Operation

The Ion Torrent Genexus System offers flexibility and cost-effective sample processing for multiple or single samples with no batching required. The automated system processes specimens with only two user touchpoints and 20 minutes of hands-on time, providing you with results in as little as 24 hours. The intuitive Genexus design enables users to acclimate quickly with minimal training, making it easy for your lab to bring NGS in-house.

Gene Fusion Detection Technology

Precision oncology research depends on targeted gene fusion. Using FusionSync™ technology, Oncomine Assays on the Genexus System offer two essential elements of fusion detection: successful sequencing and sensitivity. FusionSync enables fusion detection with limited tissue amounts and with low levels of variants in the sample so you may detect key fusions through:

Targeted known fusion detection
Non-targeted detection of novel fusion combinations
Novel fusion detection

Oncomine Solutions Brochure (PDF, 10.6 MB) Genexus System Brochure (PDF, 9.4 MB)

Reliable Oncomine Assays

Because every lab’s work is unique, we offer a variety of assays and systems to meet your individual needs. For more information on pairing next-generation sequencing instruments with Oncomine Assays, please contact your sales representative.

Oncomine Precision Assay

Targets mutations of 50 genes and performs enhanced fusion detection of multiple isoforms and novel fusions from DNA or RNA with formalin-fixed, paraffin-embedded (FFPE) or plasma samples.

Oncomine Precision Assay Flyer (PDF, 195 KB)

Oncomine Comprehensive Assay v3

Simultaneously analyzes DNA and RNA from FFPE samples, targets 143 cancer genes relevant to clinical cancer research, and detects SNVs, indels, CNVs, and fusions.

Oncomine Comprehensive Assay Plus

Provides biomarker insights for 500 genes and includes biomarkers for Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI).

Oncomine Focus Assays

Simultaneously analyzes DNA and RNA NGS from FFPE samples. Targets 52 genes relevant to solid tumors. Detect SNVs, indels, CNVs, and fusions. The Oncomine Focus Assay is only compatible with the Ion Gene Studio S5 systems.

Oncomine Myeloid Assay Gx v2

Simultaneously interrogate 45 DNA target genes and 34 fusion driver genes (RNA). This broad fusion panel allows you to sequence over 800 unique fusion transcripts. Gene content on the panel has been curated to cover relevant targets for all the major myeloid disorders—AML, MDS, MPN, CML, CMML, and JMML.

cfNA Assays

Analyze cell-free DNA and RNA for tumor type-specific NGS. Target lung, colon, and breast tumor-related samples. From a single tube of blood, detect SNVs, indels, CNVs, and fusions.