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  5. R&D Systems™ 1-Azakenpaullone

R&D Systems™ 1-Azakenpaullone
SDP

Catalog No. RD10188017 Shop All Novus Products
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RD10188017 50 mg
RD10188004 10 mg
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Catalog No. RD10188017 Supplier R&D Systems™ Supplier No. 3673/50

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Description

A Tocris product, part of R&D Systems.

1-Azakenpaullone is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 18 nM). It displays selectivity index (SI) of 111 and 233 over CDK1 and CDK5, respectively. 1-Azakenpaullone stimulates growth and replication of β-cells in vitro (rat islets) and alleviates glucolipotoxicity in INS-1 β-cells. It displays mitogenic effects on rat β-cells comparable with those of incretin hormone GIP. In combination with TTNPB (Cat. No. 0761) and WS 6 (Cat. No. 7791), 1-Azakenpaullone can be part of a chemical cocktail used for induction and long-term maintainance in vitro of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs).

Specifications

Chemical Name or Material 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
CAS 676596-65-9
Quantity 50 mg
Product Line Tocris
Target GSK-3 Inhibitors
Molecular Formula C15H10BrN3O
Purity 98%
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