1-Boc-piperazine, 99%

Description

CAS: 57260-71-6 | C9H19N2O2 | 187.26 g/mol

1-Boc-piperazine is useful for the preparation of (m-phenoxy)phenyl substituted piperazine derivatives. It is also used in the synthesis of indazole DNA gyrase inhibitors. Further, it plays an important role in the preparation of alfa,beta-poly(2-oxazoline) lipopolymers through living cationic ring opening polymerization. It is also in involved in Buchwald-Hartwig coupling reactions with aryl halides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Boc-piperazine is useful for the preparation of (m-phenoxy)phenyl substituted piperazine derivatives. It is also used in the synthesis of indazole DNA gyrase inhibitors. Further, it plays an important role in the preparation of alfa,beta-poly(2-oxazoline) lipopolymers through living cationic ring opening polymerization. It is also in involved in Buchwald-Hartwig coupling reactions with aryl halides.

Solubility
Soluble in ethyl acetate, methanol and water.

Notes
Hygroscopic. Store in a cool place. Moisture sensitive. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 57260-71-6
• Molecular Formula: C9H19N2O2
• Molecular Weight (g/mol): 187.26
• MDL Number: MFCD00075265
• InChI Key: CWXPZXBSDSIRCS-UHFFFAOYSA-O
• Synonym: 1-boc-piperazine, n-boc-piperazine, 1-n-boc-piperazine, tert-butyl 1-piperazinecarboxylate, 1-tert-butoxycarbonyl piperazine, n-t-butoxycarbonylpiperazine, boc-piperazine, n-tert-butoxycarbonylpiperazine, piperazine-1-carboxylic acid tert-butyl ester, 1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
• PubChem CID: 143452
• IUPAC Name: tert-butyl piperazine-1-carboxylate
• SMILES: CC(C)(C)OC(=O)N1CC[NH2+]CC1

• Melting Point: 44°C to 48°C
• Quantity: 1 g
• Beilstein: 879985
• Sensitivity: Air Sensitive
• Solubility Information: Soluble in ethyl acetate,methanol and water.
• Formula Weight: 186.26
• Percent Purity: 99%
• Chemical Name or Material: 1-Boc-piperazine

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
TSCA	No
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only