Alfa Aesar™ 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%

Manufacturer: Alfa Aesar™ H53139-03

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Catalog No. AAH5313903

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    Chemical Identifiers

    CAS 761446-44-0
    Molecular Formula C10H17BN2O2
    Formula Weight 208.07g/mol
    MDL Number MFCD03789259
    Synonym 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
    Chemical Name or Material 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester

    Specifications

    Melting Point 59° to 64°C
    Quantity 1g
    CAS 761446-44-0
    Molecular Formula C10H17BN2O2
    Formula Weight 208.07g/mol
    MDL Number MFCD03789259
    Synonym 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
    Health Hazard 1 Danger
    Health Hazard 2 GHS H Statement
    H301-H315-H319-H335
    Toxic if swallowed.
    Causes skin irritation.
    Causes serious eye irritation.
    May cause respiratory irritation.
    Health Hazard 3 GHS P Statement
    P261-P280-P301+P310-P305+P351+P338-P405-P501a
    Avoid breathing dust/fume/gas/mist/vapors/spray.
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
    Store locked up.
    Dispose of contents/container in accordance with local/regional/national/international regulations.
    Chemical Name or Material 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester
    Assay 97%

    Description

    Applications
    It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

    Solubility
    Slightly soluble in water.

    Notes
    Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.

    GHS H Statement
    H301-H315-H319-H335
    Toxic if swallowed.
    Causes skin irritation.
    Causes serious eye irritation.
    May cause respiratory irritation.

    GHS P Statement
    P261-P280-P301+P310-P305+P351+P338-P405-P501a
    Avoid breathing dust/fume/gas/mist/vapors/spray.
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
    Store locked up.
    Dispose of contents/container in accordance with local/regional/national/international regulations.

    Danger

    SDS & Safety Documents

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