1-Naphthyl PP1, Tocris Bioscience™

Description

Src family kinase inhibitor; also inhibits c-Abl

Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Specifications

Chemical Identifiers

• CAS: 221243-82-9
• Molecular Formula: C19H19N5
• Molecular Weight (g/mol): 317.40
• MDL Number: MFCD03425471
• InChI Key: XSHQBIXMLULFEV-UHFFFAOYSA-N
• Synonym: 1-naphthyl pp1, 1-na-pp1, pp1 analog, 1-tert-butyl-3-naphthalen-1-yl-1h-pyrazolo 3,4-d pyrimidin-4-amine, 4-amino-1-tert-butyl-3-1'-naphthyl pyrazolo 3,4-d pyrimidine, 1-1,1-dimethylethyl-3-1-naphthalenyl-1h-pyrazolo 3,4-d pyrimidin-4-amine, 1-na pp1, 1-tert-butyl-3-naphthalen-1-ylpyrazolo 3,4-d pyrimidin-4-amine
• PubChem CID: 4877
• ChEBI: CHEBI:52310
• IUPAC Name: 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• SMILES: CC(C)(C)N1N=C(C2=C(N)N=CN=C12)C1=C2C=CC=CC2=CC=C1

• Quantity: 50 mg
• Formula Weight: 317.39
• Percent Purity: >99%
• Chemical Name or Material: 1-Naphthyl PP1

Safety and Handling

Recommended Storage

Store at +4°C