Invitrogen™ LKB1 Recombinant Rabbit Monoclonal Antibody (PSH09-29)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA562889

Catalog No. MA562889

Description

Positive Control: K-562 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, COS-1 cell lysate, Mouse brain tissue lysate, Mouse testis tissue lysate, Rat testis tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue.Tissue Specificity: Low tissue specificitySubcellular Location: Nucleus, Cytoplasm, Membrane, Mitochondrion.Sequence Similarities: 92% Mouse/RatPredicted band size: 49 kDa.

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.

Specifications

• Antigen: LKB1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: D4AE59, Q15831, Q9WTK7
• Gene Symbols: STK11
• Immunogen: Recombinant protein within human LKB1 aa 1-400.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: PSH09-29
• Conjugate: Unconjugated
• Gene: STK11
• Gene Alias: AA408040; CAMK group; CAMKL family; hLKB1; liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB1; LKB-1; LKB1(S); Par-4; PJS; polarization-related protein LKB1; R75140; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11; STK11
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 20869, 314621, 6794
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid