CD337 (NKp30) Monoclonal Antibody (AF29-4D12), PE, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  LIFE TECHNOLOGIES 12337942

Catalog No. 12-337-942

Description

Description: This AF29-4D12 monoclonal antibody reacts with human CD337, which is also known as NKp30. Expressed on NK cells, CD337 is the predominant member of the natural cytotoxicity receptor family that also includes NKp46 and NKp44. CD337 is involved in activating and expanding resting NK cells following interaction with dendritic cells to eliminate tumor, virus-infected, and immature dendritic cells. Several ligands for this receptor have been reported, including B7-H6. The AF29-4D12 antibody has been reported to crossreact to rhesus macaque. Applications Reported: This AF29-4D12 antibody has been reported for use in flow cytometric analysis. Applications Tested: This AF29-4D12 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

Specifications

• Antigen: CD337 (NKp30)
• Classification: Monoclonal
• Concentration: 5 μL/Test
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: O14931, Q8MJ02
• Gene Symbols: Ncr3
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 259197, 715574
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: AF29-4D12
• Conjugate: PE
• Gene: Ncr3
• Gene Alias: 1C7; Activating natural killer receptor p30; activating NK-A1 receptor; CD337; LY117; lymphocyte antigen 117; MALS; Natural cytotoxicity triggering receptor 3; natural killer cell p30-related protein; natural killer cell receptor; Ncr3; NK receptor 1c7; Nkp30; NK-p30; NKp30S; NKp30v1; NKp30v1ED
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate, Rhesus Monkey
• Product Type: Antibody
• Isotype: IgG1 κ