MP Biomedical™ 17α-Hydroxyprogesterone Coated Tube RIA Kit

Description

Quantitative Liquid Phase Radioimmunoassay

The 17αHP Coated Tube RIA Kit is intended for the measurement of 17α-hydroxyprogesterone in unextracted serum or plasma of adults and children. The steroid 17α-hydroxyprogesterone (17αHP) is produced by both the adrenal cortex and gonads. Even though 17αHP has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17αHP, measurement of 17αHP is a useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17αHP is secreted in abundant excess. It is moderately elevated in the 11-b-hydroxylase deficiency as well. MeasuremThe 17αHP Coated Tube RIA Kit is intended for the measurement of 17α-hydroxyprogesterone in unextracted serum or plasma of adults and children. The steroid 17α-hydroxyprogesterone (17αHP) is produced by both the adrenal cortex and gonads. Even though 17αHP has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17αHP, measurement of 17αHP is a useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17αHP is secreted in abundant excess. It is moderately elevated in the 11-b-hydroxylase deficiency as well. Measurement of 17αHP is therefore valuable in the initial diagnosis of CAH.

Specifications

• Product Type: Kit and Assay
• Sample Type: Plasma, Serum
• Target Species: Human
• For Use With (Application): Endocrinology
• Quantity: 100 Tubes
• Regulatory Status: FDA Cleared (K854094/C)
• Sample Volume: 25 μL
• Storage Requirements: 2°C to 8°C